Key points Diaphragmatic fatigue (DF) elicits a sympathetically mediated metaboreflex
resulting in increased heart rate, blood pressure and limb vascular resistance. Women may …

Women are more resistant to diaphragmatic fatigue (DF) and experience an attenuated
inspiratory muscle metaboreflex relative to men. The effects of such sex-based differences …

While the traditional lung function tests are used to assess lung capacity and pulmonary
function, they cannot evaluate respiratory driving function and the integrity of the conduction …

Key points The female diaphragm fatigues at a slower rate compared to that of males, with
blunted cardiovascular consequences (ie inspiratory muscle metaboreflex). It is unclear if …

Acute intermittent hypoxia (AIH) elicits long‐term facilitation (LTF) of respiration. Although
LTF is observed when CO2 is elevated during AIH in awake humans, the influence of CO2 …

Following high‐intensity, normoxic exercise there is evidence to show that healthy females,
on average, exhibit less fatigue of the diaphragm relative to males. In the present study, we …

Abstract Diaphragm weakness in Charcot‐Marie‐Tooth disease 1A (CMT1A) is usually
associated with severe disease manifestation. This study comprehensively investigated …

Key points Under normoxic conditions, both healthy female and male diaphragms fatigue at
a similar degree when matched for absolute diaphragmatic work during inspiratory loading …

There is evidence suggesting diaphragmatic fatigue (DF) occurs relatively early during high-
intensity exercise; however, studies investigating the temporal characteristics of exercise …

The diaphragmatic motor-evoked potential (MEP) induced by transcranial magnetic
stimulation (TMS) permits electrophysiological assessment of the cortico-diaphragmatic …