With nearly 10 million deaths, cancer is the leading cause of mortality worldwide. Along with
major key parameters that control cancer treatment management, such as diagnosis …

Both genomic instability and the presence of chronic inflammation are involved in
carcinogenesis and tumor progression. These alterations predispose the cancer cells to …

Rationale: Colorectal cancer (CRC) is a common malignant tumor of the digestive system.
However, the efficacy of surgery and chemotherapy is limited. Ferroptosis is an iron-and …

At present, more than one cell death pathways have been found, one of which is ferroptosis.
Ferroptosis was discovered in 2012 and described as an iron-dependent and lipid …

Cancer cells display phenotypic equilibrium between the stem-like and differentiated states
during neoplastic homeostasis. The functional and mechanistic implications of this …

Ferroptosis is a new form of regulated cell death that is dependent on iron-and lipid reactive
oxygen species. Emerging evidence indicate that induction of ferroptosis could inhibit the …

Drug resistance is the main culprit of failure in cancer therapy that may lead to cancer
relapse. This resistance mostly originates from rare, but impactful presence of cancer stem …

Inducing ferroptosis has been acknowledged as an emerging strategy to kill drug‐resistant
tumor cells, but how to efficiently induce ferroptosis at the tumor site and enhance its …

Glioblastoma patients have a poor prognosis mainly due to temozolomide (TMZ) resistance.
NRF2 is an important transcript factor involved in chemotherapy resistance due to its …

Immunogenic cell death (ICD) through apoptosis or necroptosis is widely adopted to
improve the therapeutic effect in cancer treatment by triggering a specific antitumor …