Bacterial vaginosis: current diagnostic avenues and future opportunities
A healthy female genital tract harbors a microbiome dominated by lactic acid and hydrogen
peroxide producing bacteria, which provide protection against infections by maintaining a …
peroxide producing bacteria, which provide protection against infections by maintaining a …
Role of lactobacilli and lactoferrin in the mucosal cervicovaginal defense
P Valenti, L Rosa, D Capobianco, MS Lepanto… - Frontiers in …, 2018 - frontiersin.org
The innate defense system of the female mucosal genital tract involves a close and complex
interaction among the healthy vaginal microbiota, different cells, and various proteins that …
interaction among the healthy vaginal microbiota, different cells, and various proteins that …
The evolving facets of bacterial vaginosis: implications for HIV transmission
Bacterial vaginosis (BV) is a common yet poorly understood vaginal condition that has
become a major focus of HIV transmission and immunology research. Varied terminologies …
become a major focus of HIV transmission and immunology research. Varied terminologies …
Microbial composition predicts genital tract inflammation and persistent bacterial vaginosis in South African adolescent females
K Lennard, S Dabee, SL Barnabas… - Infection and …, 2018 - Am Soc Microbiol
Young African females are at an increased risk of HIV acquisition, and genital inflammation
or the vaginal microbiome may contribute to this risk. We studied these factors in 168 HIV …
or the vaginal microbiome may contribute to this risk. We studied these factors in 168 HIV …
[HTML][HTML] Progesterone-based compounds affect immune responses and susceptibility to infections at diverse mucosal sites
Over 100 million women worldwide are currently on progesterone-based contraceptives to
improve their health outcomes through reduced maternal mortality and family planning. In …
improve their health outcomes through reduced maternal mortality and family planning. In …
[HTML][HTML] A longitudinal analysis of the vaginal microbiota and vaginal immune mediators in women from sub-Saharan Africa
In cross-sectional studies increased vaginal bacterial diversity has been associated with
vaginal inflammation which can be detrimental for health. We describe longitudinal changes …
vaginal inflammation which can be detrimental for health. We describe longitudinal changes …
Genital inflammation, immune activation and risk of sexual HIV acquisition
JAS Passmore, HB Jaspan… - Current Opinion in HIV and …, 2016 - journals.lww.com
A genital inflammatory profile contributes to the high risk of HIV acquisition in African
women. STIs and bacterial vaginosis are poorly managed in Africa and other developing …
women. STIs and bacterial vaginosis are poorly managed in Africa and other developing …
Hormonal contraception and HIV-1 acquisition: biological mechanisms
Access to effective affordable contraception is critical for individual and public health. A wide
range of hormonal contraceptives (HCs), which differ in composition, concentration of the …
range of hormonal contraceptives (HCs), which differ in composition, concentration of the …
Hormonal contraception alters vaginal microbiota and cytokines in South African adolescents in a randomized trial
C Balle, IN Konstantinus, SZ Jaumdally… - Nature …, 2020 - nature.com
Young women in sub-Saharan Africa are disproportionally affected by HIV infection and
unintended pregnancies. However, hormonal contraceptive (HC) use may influence HIV risk …
unintended pregnancies. However, hormonal contraceptive (HC) use may influence HIV risk …
Inflammatory cytokine biomarkers of asymptomatic sexually transmitted infections and vaginal dysbiosis: a multicentre validation study
Objectives Vaginal dysbiosis and STIs are important drivers of the HIV epidemic and
reproductive complications. These conditions remain prevalent, partly because most cases …
reproductive complications. These conditions remain prevalent, partly because most cases …