“Awake” extracorporeal membrane oxygenation (ECMO): pathophysiology, technical considerations, and clinical pioneering

T Langer, A Santini, N Bottino, S Crotti, AI Batchinsky… - Critical Care, 2016 - Springer
Venovenous extracorporeal membrane oxygenation (vv-ECMO) has been classically
employed as a rescue therapy for patients with respiratory failure not treatable with …

Awake ECMO and mobilizing patients on ECMO

JY Haji, S Mehra, P Doraiswamy - Indian journal of thoracic and …, 2021 - Springer
Extracorporeal membrane oxygenation (ECMO) is a lifesaving technology in critically ill
patients who present with cardiac/pulmonary/combined cardiopulmonary failure. These …

Control of respiratory drive and effort in extracorporeal membrane oxygenation patients recovering from severe acute respiratory distress syndrome

T Mauri, G Grasselli, G Suriano, N Eronia… - …, 2016 - ingentaconnect.com
Background: The amount of extracorporeal carbon dioxide removal may influence
respiratory drive in acute respiratory distress syndrome (ARDS) patients undergoing …

Spontaneous breathing during extracorporeal membrane oxygenation in acute respiratory failure

S Crotti, N Bottino, GM Ruggeri, E Spinelli… - …, 2017 - ingentaconnect.com
Background: We evaluate the clinical feasibility of spontaneous breathing on extracorporeal
membrane oxygenation and the interactions between artificial and native lungs in patients …

[HTML][HTML] Spontaneous breathing: a double-edged sword to handle with care

T Mauri, B Cambiaghi, E Spinelli, T Langer… - Annals of …, 2017 - ncbi.nlm.nih.gov
In acute hypoxemic respiratory failure (AHRF) and acute respiratory distress syndrome
(ARDS) patients, spontaneous breathing is associated with multiple physiologic benefits: it …

Extremely high transpulmonary pressure in a spontaneously breathing patient with early severe ARDS on ECMO

T Mauri, T Langer, A Zanella, G Grasselli… - Intensive care …, 2016 - Springer
Dear Editor, Early switch of patients with severe acute respiratory distress syndrome (ARDS)
from controlled to spontaneous ventilation (ie after the first 48 h) might prevent decline of …

[HTML][HTML] Spontaneous breathing during veno-venous extracorporeal membrane oxygenation

S Crotti, N Bottino, E Spinelli - Journal of Thoracic Disease, 2018 - ncbi.nlm.nih.gov
Veno-venous extracorporeal membrane oxygenation (VV ECMO) has started to be applied
in awake spontaneously breathing patients as an alternative to invasive mechanical …

Patient Self-Inflicted Lung Injury—A Narrative Review of Pathophysiology, Early Recognition, and Management Options

P Sklienka, M Frelich, F Burša - Journal of Personalized Medicine, 2023 - mdpi.com
Patient self-inflicted lung injury (P-SILI) is a life-threatening condition arising from excessive
respiratory effort and work of breathing in patients with lung injury. The pathophysiology of P …

Intravenous autologous bone marrow–derived mesenchymal stromal cells delay acute respiratory distress syndrome in swine

AI Batchinsky, TR Roberts, B Antebi… - American Journal of …, 2023 - atsjournals.org
Rationale: Early post injury mitigation strategies in ARDS are in short supply. Treatments
with allogeneic stromal cells are administered after ARDS develops, require specialized …

How ARDS should be treated

L Gattinoni, M Quintel - Critical Care, 2016 - Springer
The Berlin definition criteria applied at positive end-expiratory pressure (PEEP) 5 cm H 2 O
reasonably predict lung edema and recruitabilty. To maintain viable gas exchange, the …