▪ Abstract The events leading to transcription of eukaryotic protein-coding genes culminate
in the positioning of RNA polymerase II at the correct initiation site. The core promoter, which …

Disulfide bonds are covalent bonds formed post-translationally by the oxidation of a pair of
cysteines. A disulfide bond can serve structural, catalytic, and signaling roles. However …

Here, we report a webserver for the improved SDM, used for predicting the effects of
mutations on protein stability. As a pioneering knowledge-based approach, SDM has been …

The role of cholesterol in eukaryotic membrane protein function has been attributed primarily
to an influence on membrane fluidity and curvature. We present the 2.8 Å resolution crystal …

Endospores produced by the Gram-positive soil bacterium Bacillus subtilis are shielded by a
proteinaceous coat formed by over 30 structural components, which self-assemble into a …

Cocrystal structures of wild-type TATA box-binding protein (TBP) recognizing 10 naturally
occurring TATA elements have been determined at 2.3–1.8 Å resolution, and compared with …

The crystal structure of the closed form of citrate synthase, with citrate and CoA bound, from
the hyperthermophilic Archaeon Pyrococcus furiosus has been determined to 1.9 Å. This …

▪ Abstract To date, high-resolution structures have been solved for five different architectural
proteins complexed to their DNA target sites. These include TATA-box–binding protein …

Electrostatic contributions to the folding free energy of several hyperthermophilic proteins
and their mesophilic homologs are calculated. In all the cases studied, electrostatic …

Abstract Background Omicron (B. 1.1. 529), a variant of SARS-CoV-2 is currently spreading
globally as a dominant strain. Due to multiple mutations at its Spike protein, including 15 …