Marine natural compounds as potents inhibitors against the main protease of SARS-CoV-2—a molecular dynamic study
Sever acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a single-stranded RNA
(ssRNA) virus, responsible for severe acute respiratory disease (COVID-19). A large number …
(ssRNA) virus, responsible for severe acute respiratory disease (COVID-19). A large number …
SARS-CoV 3CL protease cleaves its C-terminal autoprocessing site by novel subsite cooperativity
T Muramatsu, C Takemoto, YT Kim… - Proceedings of the …, 2016 - National Acad Sciences
The 3C-like protease (3CLpro) of severe acute respiratory syndrome coronavirus (SARS-
CoV) cleaves 11 sites in the polyproteins, including its own N-and C-terminal …
CoV) cleaves 11 sites in the polyproteins, including its own N-and C-terminal …
Atlas of coronavirus replicase structure
The international response to SARS-CoV has produced an outstanding number of protein
structures in a very short time. This review summarizes the findings of functional and …
structures in a very short time. This review summarizes the findings of functional and …
Proteomic discovery of protease substrates
O Schilling, CM Overall - Current opinion in chemical biology, 2007 - Elsevier
Elucidation of in vivo substrate degradomes of a protease is a daunting endeavor because
of the large number of proteins in a proteome and often minute and transient amounts of key …
of the large number of proteins in a proteome and often minute and transient amounts of key …
Profiling of Substrate Specificity of SARS-CoV 3CLpro
CP Chuck, LT Chong, C Chen, HF Chow, DCC Wan… - PloS one, 2010 - journals.plos.org
Background The 3C-like protease (3CLpro) of severe acute respiratory syndrome-
coronavirus is required for autoprocessing of the polyprotein, and is a potential target for …
coronavirus is required for autoprocessing of the polyprotein, and is a potential target for …
Mass spectrometry based proteomic studies on viruses and hosts–a review
J Zheng, RJ Sugrue, K Tang - Analytica chimica acta, 2011 - Elsevier
In terms of proteomic research in the 21st century, the realm of virology is still regarded as
an enormous challenge mainly brought by three aspects, namely, studying on the complex …
an enormous challenge mainly brought by three aspects, namely, studying on the complex …
Single‐step affinity purification of recombinant proteins using a self‐excising module from Neisseria meningitidis FrpC
L Sadilkova, R Osicka, M Sulc, I Linhartova… - Protein …, 2008 - Wiley Online Library
Purification of recombinant proteins is often a challenging process involving several
chromatographic steps that must be optimized for each target protein. Here, we developed a …
chromatographic steps that must be optimized for each target protein. Here, we developed a …
Fusion core structure of the severe acute respiratory syndrome coronavirus (SARS‐CoV): In search of potent SARS‐CoV entry inhibitors
Severe acute respiratory coronavirus (SARS‐CoV) spike (S) glycoprotein fusion core
consists of a six‐helix bundle with the three C‐terminal heptad repeat (HR2) helices packed …
consists of a six‐helix bundle with the three C‐terminal heptad repeat (HR2) helices packed …
SARS coronavirus anti-infectives
TR Tong - Frontiers in Anti-infective Drug Discovery: Volume 1, 2010 - benthamdirect.com
Severe acute respiratory syndrome (SARS) emerged in late 2002 and was controlled in July
2003 by public health measures. Its causative agent, SARS coronavirus (SARS-CoV) …
2003 by public health measures. Its causative agent, SARS coronavirus (SARS-CoV) …
Mass spectrometry for monitoring protease reactions
H Schlüter, D Hildebrand, C Gallin, A Schulz… - Analytical and …, 2008 - Springer
More than 560 genes are annotated as proteases in the human genome. About half of the
genes are not or are only marginally characterized. Over the past decade, mass …
genes are not or are only marginally characterized. Over the past decade, mass …