Sex differences in traumatic brain injury: what we know and what we should know

RP Gupte, WM Brooks, RR Vukas, JD Pierce… - Journal of …, 2019 - liebertpub.com
There is growing recognition of the problem of male bias in neuroscience research,
including in the field of traumatic brain injury (TBI) where fewer women than men are …

Melatonin and multiple sclerosis: Antioxidant, anti-inflammatory and immunomodulator mechanism of action

A Muñoz-Jurado, BM Escribano… - …, 2022 - Springer
Background Melatonin is an indole hormone secreted primarily by the pineal gland that
showing anti-oxidant, anti-inflammatory and anti-apoptotic capacity. It can play an important …

Impact of sex hormones on immune function and multiple sclerosis development

MC Ysrraelit, J Correale - Immunology, 2019 - Wiley Online Library
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system
(CNS) affecting young people and leading to demyelination and neurodegeneration. The …

Candidate mechanisms for chemotherapy-induced cognitive changes

TA Ahles, AJ Saykin - Nature Reviews Cancer, 2007 - nature.com
The mechanism (s) for chemotherapy-induced cognitive changes are largely unknown;
however, several candidate mechanisms have been identified. We suggest that shared …

Estrogen and testosterone therapies in multiple sclerosis

SM Gold, RR Voskuhl - Progress in brain research, 2009 - Elsevier
It has been known for decades that females are more susceptible than men to inflammatory
autoimmune diseases, including multiple sclerosis (MS), rheumatoid arthritis, and psoriasis …

Neurotoxicity by synthetic androgen steroids: oxidative stress, apoptosis, and neuropathology: a review

C Pomara, M Neri, S Bello, C Fiore… - Current …, 2015 - ingentaconnect.com
Anabolic-androgenic steroids (AAS) are synthetic substances derived from testosterone that
are largely employed due to their trophic effect on muscle tissue of athletes at all levels …

Neuroprotective role of steroidal sex hormones: an overview

AN Siddiqui, N Siddiqui, RA Khan… - CNS neuroscience & …, 2016 - Wiley Online Library
Progesterone, estrogens, and testosterone are the well‐known steroidal sex hormones,
which have been reported to have “nonreproductive “effects in the brain, specifically in the …

SeXX matters in multiple sclerosis

F Gilli, KD DiSano, AR Pachner - Frontiers in neurology, 2020 - frontiersin.org
Multiple sclerosis (MS) is the most common chronic inflammatory and neurodegenerative
disease of the central nervous system (CNS). An interesting feature that this debilitating …

Androgen therapy in neurodegenerative diseases

VE Bianchi, L Rizzi, E Bresciani… - Journal of the …, 2020 - academic.oup.com
Neurodegenerative diseases, including Alzheimer disease (AD), Parkinson disease (PD),
multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), and Huntington disease, are …

The role of estradiol in traumatic brain injury: mechanism and treatment potential

E Kövesdi, E Szabó-Meleg, IM Abrahám - International journal of …, 2020 - mdpi.com
Patients surviving traumatic brain injury (TBI) face numerous neurological and
neuropsychological problems significantly affecting their quality of life. Extensive studies …