AIM2 is a cytosolic innate immune receptor which recognizes double‐stranded DNA
(dsDNA) released during cellular perturbation and pathogenic assault. AIM2 recognition of …

The use of preclinical animal models of psoriasis has significantly increased over the last
three decades, with each model having unique strengths and limitations. Some models …

Psoriasis is a chronic inflammatory disorder of the skin affecting approximately 2% of the
world's population. Accumulating evidence has revealed that the IL-23/IL-17/IL-22 pathway …

The proinflammatory cytokine interleukin-1β (IL-1β) plays a central role in the pathogenesis
and the course of inflammatory skin diseases, including psoriasis. Posttranscriptional …

Summary The interleukin 1 (IL-1) pathway signals through IL-1 receptor type 1 (IL-1R1) and
emerges as a central mediator for systemic inflammation. Aberrant IL-1 signaling leads to a …

We describe a patient with an autoinflammatory disease in which the main clinical features
are pustular rash, marked osteopenia, lytic bone lesions, respiratory insufficiency, and …

The interleukin (IL)-1 family members IL-1α,-1β, and-18 are potent inflammatory cytokines
whose activities are dependent on heterodimeric receptors of the IL-1R superfamily, and …

Psoriasis is linked to systemic inflammation and cardiovascular comorbidities, but studies of
the underlying cellular mechanisms are lacking. The NLRP3 inflammasome is genetically …

Psoriasis is an ancient, universal chronic skin disease with a significant geographical
variability, with the lowest incidence rate at the equator, increasing towards the poles …

Psoriasis is a T-cell-mediated chronic inflammatory skin disease believed to be of
autoimmune nature that can be triggered or worsened by streptococcal throat infections. In …