Idiopathic pulmonary fibrosis (IPF), the most common form of idiopathic interstitial
pneumonia, is a progressive, irreversible, and typically lethal disease characterized by an …

Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrotic interstitial pneumonia
with unknown causes. The incidence rate increases year by year and the prognosis is poor …

Abstract HDAC6, a class IIB HDAC isoenzyme, stands unique in its structural and
physiological functions. Besides histone modification, largely due to its cytoplasmic …

Protein kinase B (Akt), similar to many other protein kinases, is at the crossroads of cell
death and survival, playing a pivotal role in multiple interconnected cell signaling …

Fibrotic disease is caused by the continuous deposition of extracellular matrix by persistently
activated fibroblasts (also known as myofibroblasts), even after the resolution of the injury …

Cystic Fibrosis (CF) is a genetic disorder that arises due to mutations in the Cystic Fibrosis
Transmembrane Conductance Regulator gene, which encodes for a protein responsible for …

Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease. Recent studies have
identified the key role of crosstalk between dysregulated epithelial cells, mesenchymal …

Organ fibrosis is a process in which cellular homeostasis is disrupted and extracellular
matrix is excessively deposited. Fibrosis can lead to vital organ failure and there are no …

Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with limited
therapeutic options, and there is a huge unmet need for new therapies. A growing body of …

Fibrosis usually results from dysregulated wound repair and is characterized by excessive
scar tissue. It is a complex process with unclear mechanisms. Accumulating evidence …