Resistance to cancer therapy is a major barrier to cancer management. Conventional views
have proposed that acquisition of resistance may result from genetic mutations. However …

Tissue fibrosis is a pathological condition that is associated with impaired epithelial repair
and excessive deposition of extracellular matrix (ECM). Fibrotic lesions increase the risk of …

Hippo signaling was first identified in Drosophila as a key controller of organ size by
regulating cell proliferation and anti-apoptosis. Subsequent studies have shown that this …

Our previous studies have showed that CC motif chemokine ligand 20 (CCL20) advanced
tumor progression and enhanced the chemoresistance of cancer cells by positively …

The epidermal growth factor receptor (EGFR) pathway is a well-studied oncogenic pathway
in human non-small cell lung cancer (NSCLC). A subset of advanced NSCLC patients (15 …

Simple Summary The breakthrough of immunotherapy in melanoma has generated a
glimmer of hope for lethal triple negative breast cancer (TNBC). This review summarizes the …

Cancer is a chronic disease, and it can be lethal due to limited therapeutic options. The
conventional treatment options for cancer have numerous challenges, such as a low blood …

The Hippo pathway is an evolutionary conserved signaling network that regulates essential
processes such as organ size, cell proliferation, migration, stemness and apoptosis …

The yes-associated protein (YAP) and the transcriptional coactivator with PDZ-binding motif
(TAZ) are transcriptional coactivators, members of the Hippo signaling pathway, which play …

Cancer immunotherapy is fast rising as a prominent new pillar of cancer treatment,
harnessing the immune system to fight against numerous types of cancer. Rho-kinase …