DNA methylation is a fundamentally important epigenetic modification of the mammalian
genome that has widespread influences on gene expression. During germ-cell specification …

Fundamental to genomic imprinting in mammals is the acquisition of epigenetic marks that
differ in male and female gametes at 'imprinting control regions'(ICRs). These marks mediate …

A subset of genes, known as imprinted genes, is present in the mammalian genome.
Genomic imprinting governs the monoallelic expression of these genes, depending on …

Epigenetic alterations caused by viral oncoproteins are strong initiation factors for cancer
development, but their mechanisms are largely unknown. To identify the epigenetic effects of …

A critical aspect of mammalian gametogenesis is the reprogramming of genomic DNA
methylation. The catalytically inactive adaptor Dnmt3L is essential to ensuring this occurs …

Global DNA demethylation and subsequent de novo DNA methylation take place in
mammalian male embryonic germ cells [1–3]. P-element-induced wimpy testis (PIWI) …

A stimulatory DNA methyltransferase co-factor, Dnmt3L, has evolved in mammals to assist
the process of de novo methylation, as genetically demonstrated in the germline. The …

Background Assisted reproductive technologies (ART) are widely used to treat fertility issues
in humans and for the production of embryos in mammalian livestock. The use of these …

To mimic post-ovulatory ageing, we have extended the in vitro maturation (IVM) phase to 48
h and examined effects on (i) developmental potential,(ii) expression of a panel of …

A functional role for DNA methylation has been well-established at imprinted loci, which
inherit methylation uniparentally, most commonly from the mother via the oocyte. Many CpG …