[HTML][HTML] Going below and beyond the surface: Microneedle structure, materials, drugs, fabrication, and applications for wound healing and tissue regeneration

S Lyu, Z Dong, X Xu, HP Bei, HY Yuen, CWJ Cheung… - Bioactive materials, 2023 - Elsevier
Microneedle, as a novel drug delivery system, has attracted widespread attention due to its
non-invasiveness, painless and simple administration, controllable drug delivery, and …

Hydrogel‐forming microneedles: current advancements and future trends

JG Turner, LR White, P Estrela… - Macromolecular …, 2021 - Wiley Online Library
In this focused progress review, the recent developments and trends of hydrogel‐forming
microneedles (HFMs) and potential future directions are presented. Previously …

Current trends in polymer microneedle for transdermal drug delivery

KAS Al-Japairai, S Mahmood, SH Almurisi… - International journal of …, 2020 - Elsevier
Transdermal drug delivery using microneedles is increasingly gaining interest due to the
issues associated with oral drug delivery routes. Gastrointestinal route exposes the drug to …

Down-Regulating Scar Formation by Microneedles Directly via a Mechanical Communication Pathway

Q Zhang, L Shi, H He, X Liu, Y Huang, D Xu, M Yao… - ACS …, 2022 - ACS Publications
Excessive extracellular matrix deposition drives fibroblasts into a state of high mechanical
stress, exacerbating pathological fibrosis and hypertrophic scar formation, leading to tissue …

The biomedical use of silk: past, present, future

C Holland, K Numata… - Advanced healthcare …, 2019 - Wiley Online Library
Humans have long appreciated silk for its lustrous appeal and remarkable physical
properties, yet as the mysteries of silk are unraveled, it becomes clear that this outstanding …

Silk fibroin-based biomaterials for biomedical applications: a review

TP Nguyen, QV Nguyen, VH Nguyen, TH Le… - Polymers, 2019 - mdpi.com
Since it was first discovered, thousands of years ago, silkworm silk has been known to be an
abundant biopolymer with a vast range of attractive properties. The utilization of silk fibroin …

Microneedle array systems for long-acting drug delivery

LK Vora, K Moffatt, IA Tekko, AJ Paredes… - European Journal of …, 2021 - Elsevier
The development of microneedles (MNs) assisted drug delivery technologies have been
highly active for more than two decades. The minimally invasive and self-administered MN …

Silkworm silk-based materials and devices generated using bio-nanotechnology

W Huang, S Ling, C Li, FG Omenetto… - Chemical Society …, 2018 - pubs.rsc.org
Silks are natural fibrous protein polymers that are spun by silkworms and spiders. Among
silk variants, there has been increasing interest devoted to the silkworm silk of B. mori, due …

4D printing of a bioinspired microneedle array with backward‐facing barbs for enhanced tissue adhesion

D Han, RS Morde, S Mariani… - Advanced Functional …, 2020 - Wiley Online Library
Microneedle (MN), a miniaturized needle with a length‐scale of hundreds of micrometers,
has received a great deal of attention because of its minimally invasive, pain‐free, and easy …

Silk biomaterials in wound healing and skin regeneration therapeutics: From bench to bedside

D Chouhan, BB Mandal - Acta biomaterialia, 2020 - Elsevier
Silk biomaterials are known for biomedical and tissue engineering applications including
drug delivery and implantable devices owing to their biocompatible and a wide range of …