tRNA dysregulation and disease

EA Orellana, E Siegal, RI Gregory - Nature Reviews Genetics, 2022 - nature.com
Abstract tRNAs are key adaptor molecules that decipher the genetic code during translation
of mRNAs in protein synthesis. In contrast to the traditional view of tRNAs as ubiquitously …

Noncanonical roles of tRNAs: tRNA fragments and beyond

Z Su, B Wilson, P Kumar, A Dutta - Annual review of genetics, 2020 - annualreviews.org
As one of the most abundant and conserved RNA species, transfer RNAs (tRNAs) are well
known for their role in reading the codons on messenger RNAs and translating them into …

Selective gene expression maintains human tRNA anticodon pools during differentiation

L Gao, A Behrens, G Rodschinka, S Forcelloni… - Nature Cell …, 2024 - nature.com
Transfer RNAs are essential for translating genetic information into proteins. The human
genome contains hundreds of predicted tRNA genes, many in multiple copies. How their …

RNA polymerase III transcription as a disease factor

M Yeganeh, N Hernandez - Genes & development, 2020 - genesdev.cshlp.org
RNA polymerase (Pol) III is responsible for transcription of different noncoding genes in
eukaryotic cells, whose RNA products have well-defined functions in translation and other …

The nuclear and cytoplasmic activities of RNA polymerase III, and an evolving transcriptome for surveillance

AC Kessler, RJ Maraia - Nucleic Acids Research, 2021 - academic.oup.com
A 1969 report that described biochemical and activity properties of the three eukaryotic RNA
polymerases revealed Pol III as highly distinguishable, even before its transcripts were …

A rare codon-based translational program of cell proliferation

JC Guimaraes, N Mittal, A Gnann, D Jedlinski, A Riba… - Genome biology, 2020 - Springer
Background The speed of translation elongation is primarily determined by the abundance
of tRNAs. Thus, the codon usage influences the rate with which individual mRNAs are …

Near-random distribution of chromosome-derived circular DNA in the condensed genome of pigeons and the larger, more repeat-rich human genome

HD Møller, J Ramos-Madrigal… - Genome biology and …, 2020 - academic.oup.com
Extrachromosomal circular DNA (eccDNA) elements of chromosomal origin are known to be
common in a number of eukaryotic species. However, it remains to be addressed whether …

Epigenetic regulation of human non-coding RNA gene transcription

M Morselli, G Dieci - Biochemical Society Transactions, 2022 - portlandpress.com
Recent investigations on the non-protein-coding transcriptome of human cells have
revealed previously hidden layers of gene regulation relying on regulatory non-protein …

Forces driving the three‐dimensional folding of eukaryotic genomes

A Rada‐Iglesias, FG Grosveld… - Molecular systems …, 2018 - embopress.org
The last decade has radically renewed our understanding of higher order chromatin folding
in the eukaryotic nucleus. As a result, most current models are in support of a mostly …

Extensive profiling of the expressions of tRNAs and tRNA-derived fragments (tRFs) reveals the complexities of tRNA and tRF populations in plants

X Ma, C Liu, X Kong, J Liu, S Zhang, S Liang… - Science China Life …, 2021 - Springer
Evidence is emerging that tRNA-derived fragments (tRFs) are regulatory molecules. Studies
of tRFs in plants have been based on conventional small RNA sequencing, and focused on …