The ever-increasing prevalence of noncommunicable diseases (NCDs) represents a major
public health burden worldwide. The most common form of NCD is metabolic diseases …

The ability to generate thermogenic fat could be a targeted therapy to thwart obesity and
improve metabolic health. Brown and beige adipocytes are two types of thermogenic fat …

Sympathetic innervation is essential for the development of functional beige fat that
maintains body temperature and metabolic homeostasis, yet the molecular mechanisms …

Cullin-RING E3 ubiquitin ligases (CRLs), the largest family of multi-subunit E3 ubiquitin
ligases in eukaryotic cells, represent core cellular machinery for executing protein …

FBXO28 is a member of F-box proteins that are the substrate receptors of SCF (SKP1,
CULLIN1, F-box protein) ubiquitin ligase complexes. Despite the implications of its role in …

Abstract NEDD8-conjugating enzymes, E2s, include the well-studied ubiquitin-conjugating
enzyme E2 M (UBE2M) and the poorly characterized ubiquitin-conjugating enzyme E2 F …

This study was designed to verify the anti-obesity effect of dietary turmeric powder (TP) as a
traditional cooking spice and its underlying mechanism. The HFD-fed C57BL/6J mice were …

E3 ubiquitin ligases determine the specificity of eukaryotic protein degradation by selective
binding to destabilizing protein motifs, termed degrons, in substrates for ubiquitin-mediated …

Background: Enhancing white adipose tissue (WAT) browning combats obesity. The RIIβ
subunit of cAMP-dependent protein kinase (PKA) is primarily expressed in the brain and …

Aim To investigate the effects of β‐hydroxybutyrate (BHB) and melatonin on brown adipose
tissue (BAT) plasticity in rats fed a high‐fat diet (HFD). Methods We employed a 7‐week …