The Wiskott-Aldrich syndrome (WAS) is a rare X-linked disorder with variable clinical
phenotypes that correlate with the type of mutations in the WAS protein (WASP) gene …

β2 integrins are heterodimeric surface receptors composed of a variable α (CD11a-CD11d)
and a constant β (CD18) subunit and are specifically expressed by leukocytes. The α …

Abstract Human actin-related protein 2/3 complex (Arp2/3), required for actin filament
branching, has two ARPC1 component isoforms, with ARPC1B prominently expressed in …

T cell activation and especially trafficking of T cell receptor microclusters during
immunological synapse formation are widely thought to rely on cytoskeletal remodeling …

Cytotoxic T lymphocytes (CTLs) kill by forming immunological synapses with target cells and
secreting toxic proteases and the pore-forming protein perforin into the intercellular space …

The importance of actin dynamics in the activation of the inflammasome is becoming
increasingly apparent. IL-1β, which is activated by the inflammasome, is known to be central …

Dendritic cell (DC) vaccines are used for cancer and infectious diseases, albeit with limited
efficacy. Modulating the formation of DC–T‐cell synapses may greatly increase their efficacy …

Cell-free studies have demonstrated how collective action of actin-associated proteins can
organize actin filaments into dynamic patterns, such as vortices, asters and stars. Using …

Activation of naive T cells by antigen-presenting cells (APCs) is an essential step in
mounting an adaptive immune response. It is known that antigen recognition and T cell …

Immunoactinopathies caused by mutations in actin‐related proteins are a growing group of
inborn errors of immunity (IEI). Immunoactinopathies are caused by a dysregulated actin …