Machine learning for antimicrobial resistance prediction: current practice, limitations, and clinical perspective

JI Kim, F Maguire, KK Tsang, T Gouliouris… - Clinical microbiology …, 2022 - Am Soc Microbiol
Antimicrobial resistance (AMR) is a global health crisis that poses a great threat to modern
medicine. Effective prevention strategies are urgently required to slow the emergence and …

Artificial intelligence for antimicrobial resistance prediction: challenges and opportunities towards practical implementation

T Ali, S Ahmed, M Aslam - Antibiotics, 2023 - mdpi.com
Antimicrobial resistance (AMR) is emerging as a potential threat to many lives worldwide. It
is very important to understand and apply effective strategies to counter the impact of AMR …

Acute organ injury and long-term sequelae of severe pneumococcal infections

KL Kruckow, K Zhao, DME Bowdish, CJ Orihuela - Pneumonia, 2023 - Springer
Streptococcus pneumoniae (Spn) is a major public health problem, as it is a main cause of
otitis media, community-acquired pneumonia, bacteremia, sepsis, and meningitis. Acute …

Narrow-spectrum antibacterial agents—benefits and challenges

RA Alm, SD Lahiri - Antibiotics, 2020 - mdpi.com
The number of antibacterial agents in clinical and preclinical development possessing
activity against a narrow spectrum of bacterial pathogens is increasing, with many of them …

Ten issues to update in nosocomial or hospital-acquired pneumonia: an expert review

FJ Candel, M Salavert, A Estella, M Ferrer… - Journal of Clinical …, 2023 - mdpi.com
Nosocomial pneumonia, or hospital-acquired pneumonia (HAP), and ventilator-associated
pneumonia (VAP) are important health problems worldwide, with both being associated with …

Best diagnostic accuracy of sepsis combining SIRS criteria or qSOFA score with Procalcitonin and Mid-Regional pro-Adrenomedullin outside ICU

S Spoto, E Nobile, EPR Carnà, M Fogolari, D Caputo… - Scientific Reports, 2020 - nature.com
Early diagnosis and treatment significantly reduce sepsis mortality. Currently, no gold
standard has been yet established to diagnose sepsis outside the ICU. The aim of the study …

In vitro synergy of the combination of sulbactam-durlobactam and cefepime at clinically relevant concentrations against A. baumannii, P. aeruginosa and …

A Fouad, DP Nicolau, CM Gill - Journal of Antimicrobial …, 2023 - academic.oup.com
Background Sulbactam-durlobactam is a potent combination active against Acinetobacter
baumannii; however, it lacks activity against other nosocomial pathogens. Cefepime is a …

Acinetobacter spp. bloodstream infection in hematological patients: a 10-year single-center study

J Li, X Feng, J Wang, Q Lin, Y Zheng, F Zhang… - BMC Infectious …, 2023 - Springer
Purpose This study investigated the clinical and antimicrobial characteristics of
Acinetobacter spp. bloodstream infection (BSI) in hematological patients. Risk factors for 30 …

Key challenges in providing effective antibiotic therapy for critically ill patients with bacterial sepsis and septic shock

CB Landersdorfer, RL Nation - Clinical Pharmacology & …, 2021 - Wiley Online Library
Early initiation of effective antibiotic therapy is vitally important for saving the lives of critically
ill patients with sepsis or septic shock. The susceptibility of the infecting pathogen and the …

Pathogen-targeted clinical development to address unmet medical need: design, safety, and efficacy of the ATTACK trial

RR Watkins, B Du, R Isaacs… - Clinical Infectious …, 2023 - academic.oup.com
There is a crucial need for novel antibiotics to stem the tide of antimicrobial resistance,
particularly against difficult to treat gram-negative pathogens like Acinetobacter baumannii …