Purinergic signalling, ie, the role of nucleotides as extracellular signalling molecules, was
proposed in 1972. However, this concept was not well accepted until the early 1990's when …

The root cause of preeclampsia is the placenta. Preeclampsia begins to abate with the
delivery of the placenta and can occur in the absence of a fetus but with the presence of …

Natural killer (NK) cells are found in lymphoid and non-lymphoid organs. In addition to
important roles in immune surveillance, some NK cells contribute to angiogenesis and …

Inflammation is known to be associated with placental dysfunction and pregnancy
complications. Infections are well known to be a cause of inflammation but they are …

Adenosine kinase (ADK) is the key regulator of adenosine and catalyzes the metabolism of
adenosine to 5′-adenosine monophosphate. The enzyme exists in two isoforms: a long …

A balanced communication between the mother, placenta and foetus is crucial to reach a
successful pregnancy. Several windows of exposure to environmental toxins are present …

Maternal tolerance to semi‐or fully allograft conceptus is a prerequisite for the maintenance
of pregnancy. Once this homeostasis is disrupted, it may result in pregnancy loss. As a …

Adenosine is an endogenous nucleoside with pleiotropic effects in different physiological
processes including circulation, renal blood flow, immune function, or glucose homeostasis …

There are multiple roles for purinergic signalling in both male and female reproductive
organs. ATP, released as a cotransmitter with noradrenaline from sympathetic nerves …

Reduced mitochondrial oxidative phosphorylation, via activation of adenylate kinase and the
resulting exponential rise in the cellular AMP/ATP ratio, appears to be a critical factor …