Immune targets for therapeutic development in depression: towards precision medicine
Over the past two decades, compelling evidence has emerged indicating that immune
mechanisms can contribute to the pathogenesis of major depressive disorder (MDD) and …
mechanisms can contribute to the pathogenesis of major depressive disorder (MDD) and …
Peripheral blood cellular immunophenotype in depression: a systematic review and meta-analysis
ÉM Foley, JT Parkinson, RE Mitchell, L Turner… - Molecular …, 2023 - nature.com
Introduction Meta-analyses implicate immune dysfunction in depression confirming
increased levels of circulating immune proteins (eg, cytokines) in depression cases …
increased levels of circulating immune proteins (eg, cytokines) in depression cases …
Association of inflammation with depression and anxiety: evidence for symptom-specificity and potential causality from UK Biobank and NESDA cohorts
Y Milaneschi, N Kappelmann, Z Ye, F Lamers… - Molecular …, 2021 - nature.com
We examined whether inflammation is uniformly associated with all depressive and anxiety
symptoms, and whether these associations are potentially causal. Data was from 147,478 …
symptoms, and whether these associations are potentially causal. Data was from 147,478 …
New insights from the last decade of research in psychiatric genetics: discoveries, challenges and clinical implications
Psychiatric genetics has made substantial progress in the last decade, providing new
insights into the genetic etiology of psychiatric disorders, and paving the way for precision …
insights into the genetic etiology of psychiatric disorders, and paving the way for precision …
Therapeutic potential of IL6R blockade for the treatment of sepsis and sepsis-related death: A Mendelian randomisation study
Background Sepsis is characterised by dysregulated, life-threatening immune responses,
which are thought to be driven by cytokines such as interleukin 6 (IL-6). Genetic variants in …
which are thought to be driven by cytokines such as interleukin 6 (IL-6). Genetic variants in …
Inflammation and brain structure in schizophrenia and other neuropsychiatric disorders: a Mendelian randomization study
Importance Previous in vitro and postmortem research suggests that inflammation may lead
to structural brain changes via activation of microglia and/or astrocytic dysfunction in a range …
to structural brain changes via activation of microglia and/or astrocytic dysfunction in a range …
[HTML][HTML] Associations of immunological proteins/traits with schizophrenia, major depression and bipolar disorder: A bi-directional two-sample mendelian …
Background Schizophrenia, bipolar disorder and depression are associated with
inflammation. However, it is unclear whether associations of immunological proteins/traits …
inflammation. However, it is unclear whether associations of immunological proteins/traits …
Association between systemic inflammation and individual symptoms of depression: a pooled analysis of 15 population-based cohort studies
Objective: Evidence from anti-inflammatory drug trials for the treatment of depression has
been inconsistent. This may be ascribed to the differing symptom-specific effects of …
been inconsistent. This may be ascribed to the differing symptom-specific effects of …
Obesity and psychological distress
The relationship between high body weight and mental health has been studied for several
decades. Improvements in the quality of epidemiological, mechanistic and psychological …
decades. Improvements in the quality of epidemiological, mechanistic and psychological …
Burning down the house: reinventing drug discovery in psychiatry for the development of targeted therapies
AH Miller, CL Raison - Molecular Psychiatry, 2023 - nature.com
Despite advances in neuroscience, limited progress has been made in developing new and
better medications for psychiatric disorders. Available treatments in psychiatry rely on a few …
better medications for psychiatric disorders. Available treatments in psychiatry rely on a few …