To address the continued rise of multi-drug-resistant microorganisms, the development of
novel drugs with new modes of action is urgently required. While humans biosynthesize the …

Important pathogens such as Mycobacterium tuberculosis and Plasmodium falciparum, the
causative agents of tuberculosis and malaria, respectively, and plants, utilize the 2 C-methyl …

Antimicrobial drug resistance is an urgent problem in the control and treatment of many of
the world's most serious infections, including Plasmodium falciparum malaria, tuberculosis …

The human malaria parasite Plasmodium falciparum is responsible for the deaths of more
than a million people each year. Fosmidomycin has been proven to be efficient in the …

The non-mevalonate pathway of isoprenoid (terpenoid) biosynthesis is essential in many
eubacteria including the major human pathogen, Mycobacterium tuberculosis, in …

Background Highly charged compounds typically suffer from low membrane permeability
and thus are generally regarded as sub-optimal drug candidates. Nonetheless, the highly …

The methyl erythritol phosphate (MEP) pathway of isoprenoid biosynthesis is essential for
malaria parasites and also for several human pathogenic bacteria, thus representing an …

The natural antibiotic fosmidomycin acts via inhibition of 1-deoxy-d-xylulose 5-phosphate
reductoisomerase (DXR), an essential enzyme in the non-mevalonate pathway of …

Isoprene biosynthesis is an essential component of metabolism. Two pathways are known
for the production of five-carbon (isoprene) intermediates: the mevalonate and …

Reverse hydroxamate-based inhibitors of IspC, a key enzyme of the non-mevalonate
pathway of isoprenoid biosynthesis and a validated antimalarial target, were synthesized …