Personalized medicine in psychiatry: problems and promises
U Ozomaro, C Wahlestedt, CB Nemeroff - BMC medicine, 2013 - Springer
The central theme of personalized medicine is the premise that an individual's unique
physiologic characteristics play a significant role in both disease vulnerability and in …
physiologic characteristics play a significant role in both disease vulnerability and in …
Unravelling the genetic basis of schizophrenia and bipolar disorder with GWAS: A systematic review
Objectives To systematically review findings of GWAS in schizophrenia (SZ) and in bipolar
disorder (BD); and to interpret findings, with a focus on identifying independent replications …
disorder (BD); and to interpret findings, with a focus on identifying independent replications …
A comprehensive family-based replication study of schizophrenia genes
Importance Schizophrenia (SCZ) is a devastating psychiatric condition. Identifying the
specific genetic variants and pathways that increase susceptibility to SCZ is critical to …
specific genetic variants and pathways that increase susceptibility to SCZ is critical to …
Expression of ZNF804A in human brain and alterations in schizophrenia, bipolar disorder, and major depressive disorder: a novel transcript fetally regulated by the …
Importance The single-nucleotide polymorphism rs1344706 in the zinc finger protein 804A
gene (ZNF804A) shows genome-wide association with schizophrenia and bipolar disorder …
gene (ZNF804A) shows genome-wide association with schizophrenia and bipolar disorder …
ZNF804a regulates expression of the schizophrenia-associated genes PRSS16, COMT, PDE4B, and DRD2
ZNF804a was identified by a genome-wide association study (GWAS) in which a single
nucleotide polymorphism (SNP rs1344706) in ZNF804a reached genome-wide statistical …
nucleotide polymorphism (SNP rs1344706) in ZNF804a reached genome-wide statistical …
Knockdown of the psychosis susceptibility gene ZNF804A alters expression of genes involved in cell adhesion
Genome-wide association studies have convincingly implicated several novel genes in
susceptibility to schizophrenia and bipolar disorder. The first genome-wide significant …
susceptibility to schizophrenia and bipolar disorder. The first genome-wide significant …
The schizophrenia risk gene ZNF804A: clinical associations, biological mechanisms and neuronal functions
H Chang, X Xiao, M Li - Molecular psychiatry, 2017 - nature.com
ZNF804A (zinc-finger protein 804A) has been recognized as a schizophrenia risk gene
across multiple world populations. Its intronic single-nucleotide polymorphism (SNP) …
across multiple world populations. Its intronic single-nucleotide polymorphism (SNP) …
Genetics of psychiatric disorders in the GWAS era: an update on schizophrenia
SG Schwab, DB Wildenauer - European archives of psychiatry and clinical …, 2013 - Springer
The influence of genetic factors in the development of schizophrenia has been convincingly
demonstrated by family, twin, and adoption studies. The statistical construct of heritability is …
demonstrated by family, twin, and adoption studies. The statistical construct of heritability is …
Evidence That Schizophrenia Risk Variation in the ZNF804A Gene Exerts Its Effects During Fetal Brain Development
MJ Hill, NJ Bray - American Journal of Psychiatry, 2012 - Am Psychiatric Assoc
Objective The single-nucleotide polymorphism rs1344706, located within an intron of the
ZNF804A gene, exhibits genome-wide significant association with schizophrenia. Although …
ZNF804A gene, exhibits genome-wide significant association with schizophrenia. Although …
Interactome analysis reveals ZNF804A, a schizophrenia risk gene, as a novel component of protein translational machinery critical for embryonic neurodevelopment
Recent genome-wide association studies identified over 100 genetic loci that significantly
associate with schizophrenia (SZ). A top candidate gene, ZNF804A, was robustly replicated …
associate with schizophrenia (SZ). A top candidate gene, ZNF804A, was robustly replicated …