All cancers tested so far display abnormal choline and ethanolamine phospholipid
metabolism, which has been detected with numerous magnetic resonance spectroscopy …

Abnormal choline metabolism continues to be identified in multiple cancers. Molecular
causes of abnormal choline metabolism are changes in choline kinase-α, ethanolamine …

Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic malignancy for which there
are currently no effective anti-metastatic therapies. Herein, we employed single-cell RNA …

Pancreatic cancer is the third leading cause of cancer death in the United States, and the 5-
year relative survival for patients diagnosed with pancreatic cancer is less than 10%. Early …

It is well established that lipid metabolism is drastically altered during tumor development
and response to therapy. Choline kinase alpha (ChoKα) is a key mediator of these changes …

Introduction Hypoxia is one of the important reasons for the poor therapeutic efficacy of
current pancreatic cancer treatment, and the dense stroma of pancreatic cancer restricts the …

This review provides a summary of recent discoveries in choline transport and the proteins
mediating it with a specific focus on the choline transporter-like proteins (CTL)/solute carriers …

Purpose To correlate the clinical stage and prognosis of pancreatic or periampullary cancer
with the imaging biomarkers on diffusion-weighted imaging, magnetic resonance …

Abstract Background Pancreatic adenocarcinomas (PAs) have very poor prognoses even
when surgery is possible. Currently, there are no tissular biomarkers to predict long-term …

Our study aimed to identify a urinary metabolite panel for the detection/diagnosis of
pancreatic ductal adenocarcinoma (PDAC). PDAC continues to have poor survival …