CaMKII: a central molecular organizer of synaptic plasticity, learning and memory
Abstract Calcium–calmodulin (CaM)-dependent protein kinase II (CaMKII) is the most
abundant protein in excitatory synapses and is central to synaptic plasticity, learning and …
abundant protein in excitatory synapses and is central to synaptic plasticity, learning and …
NMDA receptor functions in health and disease: Old actor, new dimensions
N-Methyl-D-aspartate ionotropic glutamate receptors (NMDARs) play key roles in
synaptogenesis, synaptic maturation, long-term plasticity, neuronal network activity, and …
synaptogenesis, synaptic maturation, long-term plasticity, neuronal network activity, and …
CaMKII: claiming center stage in postsynaptic function and organization
JW Hell - Neuron, 2014 - cell.com
While CaMKII has long been known to be essential for synaptic plasticity and learning,
recent work points to new dimensions of CaMKII function in the nervous system, revealing …
recent work points to new dimensions of CaMKII function in the nervous system, revealing …
Excitation–transcription coupling, neuronal gene expression and synaptic plasticity
Excitation–transcription coupling (E–TC) links synaptic and cellular activity to nuclear gene
transcription. It is generally accepted that E–TC makes a crucial contribution to learning and …
transcription. It is generally accepted that E–TC makes a crucial contribution to learning and …
Regulation of NMDA glutamate receptor functions by the GluN2 subunits
The N‐methyl‐D‐aspartate receptors (NMDARs) are ionotropic glutamate receptors that
mediate the flux of calcium (Ca2+) into the post‐synaptic compartment. Ca2+ influx …
mediate the flux of calcium (Ca2+) into the post‐synaptic compartment. Ca2+ influx …
CK2 regulation: perspectives in 2021
SE Roffey, DW Litchfield - Biomedicines, 2021 - mdpi.com
The protein kinase CK2 (CK2) family encompasses a small number of acidophilic
serine/threonine kinases that phosphorylate substrates involved in numerous biological …
serine/threonine kinases that phosphorylate substrates involved in numerous biological …
Regulation of sympathetic vasomotor activity by the hypothalamic paraventricular nucleus in normotensive and hypertensive states
RA Dampney, LC Michelini, DP Li… - American Journal of …, 2018 - journals.physiology.org
The hypothalamic paraventricular nucleus (PVN) is a unique and important brain region
involved in the control of cardiovascular, neuroendocrine, and other physiological functions …
involved in the control of cardiovascular, neuroendocrine, and other physiological functions …
MAGUKs: multifaceted synaptic organizers
Highlights•PSD-95 and PSD-93 are essential for PSD structure.•SAP102 plays a role in
clearing NMDARs from the synapse.•PSD-95 sculpts protein content at the PSD.•PSD-93 …
clearing NMDARs from the synapse.•PSD-95 sculpts protein content at the PSD.•PSD-93 …
Dynamic regulation of N-methyl-d-aspartate (NMDA) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors by posttranslational modifications
MP Lussier, A Sanz-Clemente, KW Roche - Journal of Biological Chemistry, 2015 - ASBMB
Many molecular mechanisms underlie the changes in synaptic glutamate receptor content
that are required by neuronal networks to generate cellular correlates of learning and …
that are required by neuronal networks to generate cellular correlates of learning and …