The activation of a substrate by a chiral catalyst is now regarded as one of the most powerful
strategies that can be employed in the art of asymmetric synthesis. 1 The development of …

Figure 73: The proposed catalyst/substrate interaction shown in Figure 73 corresponds to
the related sulfoxidation catalyzed by chiral phosphoric acid PA 5 (ref 133). Please note that …

Mechanistic and computational studies were conducted to elucidate the mechanism and the
origins of enantiocontrol for asymmetric chiral phosphoric acid-catalyzed spiroketalization …

Two catalysts, an amine HCl salt and a bisthiourea, work in concert to enable the generation
of oxocarbenium ions under mild conditions. The amine catalyst generates an iminium ion of …

In recent years, the field of organocatalysis has extensively explored the use of carbenium
ions for practical C− C bond forming reactions. In order to control the formation of new …

Carbocations stabilized by adjacent oxygen atoms are useful reactive intermediates
involved in fundamental chemical transformations. These oxocarbenium ions typically lack …

Ionic hydrogenation has not been extensively explored, but is advantageous for challenging
substrates such as unsaturated intermediates. Reported here is an iridium‐catalyzed …

We report an unprecedented organocatalytic enantioselective acyloin rearrangement of α, α‐
disubstituted α‐hydroxy acetals. In the presence of a catalytic amount of chiral binol‐derived …

An enantioselective intramolecular chiral phosphoric acid‐catalyzed cyclization of
unsaturated acetals has been utilized for the synthesis of functionalized chiral piperidines …

Chiral phosphoric acids have emerged as promising asymmetric Brønsted acid catalysts that
harness hydrogen bonding interactions as key stereocontrolling elements. A new approach …