Neuro–bone tissue engineering: emerging mechanisms, potential strategies, and current challenges

W Sun, B Ye, S Chen, L Zeng, H Lu, Y Wan, Q Gao… - Bone Research, 2023 - nature.com
The skeleton is a highly innervated organ in which nerve fibers interact with various skeletal
cells. Peripheral nerve endings release neurogenic factors and sense skeletal signals …

Advances in tissue engineering of gellan gum-based hydrogels

S Wu, R Xiao, Y Wu, L Xu - Carbohydrate Polymers, 2024 - Elsevier
Gellan Gum (GG) is a large, naturally occurring, linear polysaccharide with a similar
structure and biological properties to the extracellular matrix. It's appropriate as a matrix …

Core transcription programs controlling injury-induced neurodegeneration of retinal ganglion cells

F Tian, Y Cheng, S Zhou, Q Wang, A Monavarfeshani… - Neuron, 2022 - cell.com
Regulatory programs governing neuronal death and axon regeneration in
neurodegenerative diseases remain poorly understood. In adult mice, optic nerve crush …

[HTML][HTML] 3D bio-printed living nerve-like fibers refine the ecological niche for long-distance spinal cord injury regeneration

J Yang, K Yang, W Man, J Zheng, Z Cao, CY Yang… - Bioactive Materials, 2023 - Elsevier
Abstract 3D bioprinting holds great promise toward fabricating biomimetic living constructs in
a bottom-up assembly manner. To date, various emergences of living constructs have been …

ROS‐Scavenging Hydrogels Synergize with Neural Stem Cells to Enhance Spinal Cord Injury Repair via Regulating Microenvironment and Facilitating Nerve …

D Liu, G Lu, B Shi, H Ni, J Wang, Y Qiu… - Advanced …, 2023 - Wiley Online Library
Although stem cell‐based therapy is recognized as a promising therapeutic strategy for
spinal cord injury (SCI), its efficacy is greatly limited by local reactive oxygen species (ROS) …

Recent advance in bioactive hydrogels for repairing spinal cord injury: material design, biofunctional regulation, and applications

Z Sun, D Zhu, H Zhao, J Liu, P He, X Luan, H Hu… - Journal of …, 2023 - Springer
Functional hydrogels show potential application in repairing spinal cord injury (SCI) due to
their unique chemical, physical, and biological properties and functions. In this …

Retinal ganglion cell repopulation for vision restoration in optic neuropathy: a roadmap from the RReSTORe Consortium

JR Soucy, EA Aguzzi, J Cho, MJ Gilhooley… - Molecular …, 2023 - Springer
Retinal ganglion cell (RGC) death in glaucoma and other optic neuropathies results in
irreversible vision loss due to the mammalian central nervous system's limited regenerative …

Physical cue‐based strategies on peripheral nerve regeneration

Z Wei, F Jin, T Li, L Qian, W Zheng… - Advanced Functional …, 2023 - Wiley Online Library
Peripheral nerve injury (PNI) remains an intractable challenge in regenerative medicine.
Recently, physical cue‐based strategies (eg, electrical neurostimulation, acoustic radiation …

Transcriptional control of peripheral nerve regeneration

Y Zhang, Q Zhao, Q Chen, L Xu, S Yi - Molecular Neurobiology, 2023 - Springer
Transcription factors are master regulators of various cellular processes under diverse
physiological and pathological conditions. Many transcription factors that are differentially …

Cell development enhanced bionic silk hydrogel on remodeling immune pathogenesis of spinal cord injury via m2 polarization of microglial

J Ling, T Huang, R Wu, C Ma, G Lin… - Advanced Functional …, 2023 - Wiley Online Library
Due to the complex spatial‐temporal pathophysiology of spinal cord injury (SCI), effective
modulation of SCI‐specific inflammatory pathogenesis to achieve desirable therapeutic …