Gene–environment interactions in Alzheimer disease: the emerging role of epigenetics

L Migliore, F Coppedè - Nature Reviews Neurology, 2022 - nature.com
With the exception of a few monogenic forms, Alzheimer disease (AD) has a complex
aetiology that is likely to involve multiple susceptibility genes and environmental factors. The …

Involvement of lipids in Alzheimer's disease pathology and potential therapies

H Chew, VA Solomon, AN Fonteh - Frontiers in physiology, 2020 - frontiersin.org
Lipids constitute the bulk of the dry mass of the brain and have been associated with healthy
function as well as the most common pathological conditions of the brain. Demographic …

[HTML][HTML] Global survey of the omega-3 fatty acids, docosahexaenoic acid and eicosapentaenoic acid in the blood stream of healthy adults

KD Stark, ME Van Elswyk, MR Higgins… - Progress in lipid …, 2016 - Elsevier
Studies reporting blood levels of the omega-3 polyunsaturated fatty acids, eicosapentaenoic
acid (EPA) and docosahexaenoic acid (DHA), were systematically identified in order to …

[HTML][HTML] Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease

AR Nelson, MD Sweeney, AP Sagare… - Biochimica et Biophysica …, 2016 - Elsevier
Vascular insults can initiate a cascade of molecular events leading to neurodegeneration,
cognitive impairment, and dementia. Here, we review the cellular and molecular …

DHA effects in brain development and function

L Lauritzen, P Brambilla, A Mazzocchi, LBS Harsløf… - Nutrients, 2016 - mdpi.com
Docosahexaenoic acid (DHA) is a structural constituent of membranes specifically in the
central nervous system. Its accumulation in the fetal brain takes place mainly during the last …

Docosahexaenoic acid and cognition throughout the lifespan

MJ Weiser, CM Butt, MH Mohajeri - Nutrients, 2016 - mdpi.com
Docosahexaenoic acid (DHA) is the predominant omega-3 (n-3) polyunsaturated fatty acid
(PUFA) found in the brain and can affect neurological function by modulating signal …

Health benefits of docosahexaenoic acid and its bioavailability: A review

J Li, BLR Pora, K Dong, J Hasjim - Food Science & Nutrition, 2021 - Wiley Online Library
Docosahexaenoic acid (DHA) is the predominant omega‐3 long‐chain polyunsaturated fatty
acid found in human brain and eyes. There are a number of studies in the literature showing …

How does high DHA fish oil affect health? A systematic review of evidence

S Ghasemi Fard, F Wang, AJ Sinclair… - Critical reviews in …, 2019 - Taylor & Francis
The health benefits of fish oil, and its omega-3 long chain polyunsaturated fatty acid content,
have attracted much scientific attention in the last four decades. Fish oils that contain higher …

[HTML][HTML] Nutritional factors affecting adult neurogenesis and cognitive function

SM Poulose, MG Miller, T Scott, B Shukitt-Hale - Advances in nutrition, 2017 - Elsevier
Adult neurogenesis, a complex process by which stem cells in the hippocampal brain region
differentiate and proliferate into new neurons and other resident brain cells, is known to be …

[HTML][HTML] Impact of maternal diet on human milk composition and neurological development of infants

SM Innis - The American journal of clinical nutrition, 2014 - Elsevier
Maternal nutrition has little or no effect on many nutrients in human milk; for others, human
milk may not be designed as a primary nutritional source for the infant; and for a few …