The ubiquitin–proteasome system (UPS) plays an important role in the cellular processes for
protein quality control and homeostasis. Dysregulation of the UPS has been implicated in …

Breast cancer (BC) has been ranked the most common malignant tumor throughout the
world and is also a leading cause of cancer-related deaths among women. SRC family …

As the most frequent and vulnerable malignancy among women, breast cancer universally
manifests a formidable healthcare challenge. From a biological and molecular perspective, it …

Background Increasing evidence suggests that immunotherapy, especially immune
checkpoint inhibitors (ICIs), has the potential to facilitate long-term survival in various cancer …

Activation of the tyrosine kinase c-Src promotes breast cancer progression and poor
outcomes, yet the underlying mechanisms are incompletely understood. Here, we have …

The anaphase promoting complex/cyclosome (APC/C), is an evolutionarily conserved
protein complex essential for cellular division due to its role in regulating the mitotic …

Simple Summary The ubiquitin proteasome system (UPS) governs the non-lysosomal
degradation of oxidized, damaged, or misfolded proteins in eukaryotic cells. Dysregulation …

Ubiquitination is a multi-step enzymatic process that involves the marking of a substrate
protein by bonding a ubiquitin and protein for proteolytic degradation mainly via the ubiquitin …

Transforming growth factor–β (TGF-β) signaling has important roles during embryonic
development and in tissue homeostasis. TGF-β ligands exert cellular effects by binding to …

Doxorubicin (Doxo) is the most effective chemotherapeutic agent for the treatment of breast
cancer. However, resistance to Doxo is common. Adjuvant compounds capable of …