Immune escape and attenuated severity associated with the SARS-CoV-2 BA. 2.86/JN. 1 lineage

JA Lewnard, P Mahale, D Malden, V Hong… - Nature …, 2024 - nature.com
Abstract The SARS-CoV-2 BA. 2.86 lineage, and its sublineage JN. 1 in particular, achieved
widespread transmission in the US during winter 2023–24. However, this surge in infections …

Structure-guided mutations in CDRs for enhancing the affinity of neutralizing SARS-CoV-2 nanobody

V Singh, M Bhutkar, S Choudhary, S Nehul… - Biochemical and …, 2024 - Elsevier
The optimization of antibodies to attain the desired levels of affinity and specificity holds
great promise for the development of next generation therapeutics. This study delves into the …