Cancer development is driven by the accumulation of alterations affecting the structure and
function of the genome. Whereas genetic changes disrupt the DNA sequence, epigenetic …

Over the past decade, various liquid biopsy techniques have emerged as viable alternatives
to the analysis of traditional tissue biopsy samples. Such surrogate 'biopsies' offer numerous …

This article reviews recent developments in the application of cell-free DNA-based liquid
biopsies to neurological diseases. Over the past few decades, an explosion of interest in the …

Abstract Background Diffuse Midline Glioma (DMG) with the H3K27M mutation is a lethal
childhood brain cancer, with patients rarely surviving 2 years from diagnosis. Methods We …

Medulloblastoma (MB) is the most common malignant brain tumor in children. There
remains an unmet need for diagnostics to sensitively detect the disease, particularly …

Simple Summary ctDNA is a small DNA fragment derived from tumor cells, which contains
tumor-related genomic information, such as mutation, methylation, microsatellite instability …

Simple Summary The optimal treatment and management of patients with brain cancer
depend on the molecular characteristics of their tumour. Since the tumour changes with time …

Hepatocellular carcinoma (HCC) is amongst the cancers with highest mortality rates and is
the most common malignancy of the liver. Early detection is vital to provide the best …

Abstract Purpose of Review Review recent advances in the understanding of pediatric
medulloblastoma including etiology, biology, radiology, and management of pediatric …

Background Brain cancer is the leading cause of cancer-related death in children. Early
detection and serial monitoring are essential for better therapeutic outcomes. Liquid biopsy …