In high-, middle-and low-income countries, the rising prevalence of obesity is the underlying
cause of numerous health complications and increased mortality. Being a complex and …

Until just a few years ago, the genetic determinants of obesity and metabolic syndrome were
largely unknown, with the exception of a few forms of monogenic extreme obesity. Since …

C-reactive protein (CRP) is a sensitive biomarker of chronic low-grade inflammation and is
associated with multiple complex diseases. The genetic determinants of chronic …

Asthma exacerbations are among the most frequent causes of hospitalization during
childhood, but the underlying mechanisms are poorly understood. We performed a genome …

Motivation DNA methylation datasets are growing ever larger both in sample size and
genome coverage. Novel computational solutions are required to efficiently handle these …

Background Low plasma 25-hydroxyvitamin D (25 [OH] D) concentration is associated with
high arterial blood pressure and hypertension risk, but whether this association is causal is …

Background Despite evidence that genetic factors contribute to the duration of gestation and
the risk of preterm birth, robust associations with genetic variants have not been identified …

Approaches exploiting trait distribution extremes may be used to identify loci associated with
common traits, but it is unknown whether these loci are generalizable to the broader …

Coordinated international action to accelerate genome-to-phenome with FAANG, the
Functional Annotation of Animal Genomes project | Genome Biology Skip to main content …

Common and rare variants associated with body mass index (BMI) and obesity account for<
5% of the variance in BMI. We performed SNP and copy number variation (CNV) association …