An update on the role of irisin in the regulation of endocrine and metabolic functions

MO Mahgoub, C D'Souza, RSMH Al Darmaki… - Peptides, 2018 - Elsevier
Irisin is a novel myokine and adipokine that has gained much attention recently due to its
mechanisms of action. Irisin is secreted following proteolytic cleavage of its precursor …

Irisin at the crossroads of inter-organ communications: Challenge and implications

R Zhao - Frontiers in Endocrinology, 2022 - frontiersin.org
The physiological functions of organs are intercommunicated occurring through secreted
molecules. That exercise can improve the physiological function of organs or tissues is …

Irisin attenuates acute glaucoma-induced neuroinflammation by activating microglia-integrin αVβ5/AMPK and promoting autophagy

Q Zhang, S Xiang, X Chen, Y Rong, L Huang… - International …, 2024 - Elsevier
Neuroinflammation, characterized by microglial activation and the release of multiple
inflammatory mediators, is a key factor in acute glaucomatous injury leading to retinal …

The changes of irisin and inflammatory cytokines in the age-related macular degeneration and retinal vein occlusion

X Li, X Cao, M Zhao, Y Bao - Frontiers in Endocrinology, 2022 - frontiersin.org
Purpose Age-related macular degeneration (AMD) and retinal vein occlusion (RVO) are
irreversible chorioretinal diseases, which might induce severe damage in visual function …

Irisin: A bridge between exercise and neurological diseases

Y Zhang, X Zhang, S Lin - Heliyon, 2022 - cell.com
Exercise plays a beneficial regulating role on each organ of the body through different
mechanisms and is a powerful weapon to prevent disease. Irisin is released from muscle …

Metabolic disorders/obesity is a primary risk factor in hidradenitis suppurativa: an immunohistochemical real-world approach

KP Kaleta, G Nikolakis, AM Hossini, O Balthasar… - Dermatology, 2022 - karger.com
Background: Hidradenitis suppurativa (HS) is an inflammatory, potentially scarring disease
of the hair follicle, affecting the apocrine gland-bearing skin areas. The major comorbid …

Molecular basis of irisin regulating the effects of exercise on insulin resistance

J Lin, X Liu, Y Zhou, B Zhu, Y Wang, W Cui, Y Peng… - Applied Sciences, 2022 - mdpi.com
Insulin resistance is recognized as one major feature of metabolic syndrome, and frequently
emerges as a difficult problem encountered during long-term pharmacological treatment of …

Immunohistochemical localization of irisin in mole rats (Spalax leucodon)

FM Gür, S Timurkaan, MH Yalcin, A Girgin… - Biotechnic & …, 2017 - Taylor & Francis
Irisin was first identified in skeletal muscle cells. It is an exercise protein that is secreted into
the circulation; it causes conversion of white adipose tissue to brown adipose tissue. We …

The association between irisin and muscle metabolism in different thyroid disorders

A Zybek‐Kocik, N Sawicka‐Gutaj… - Clinical …, 2018 - Wiley Online Library
Background Irisin is a new adipo‐myokine, encoded by the FNDC 5 gene. Currently, there is
a discussion regarding the relation between thyroid function and irisin concentration. This …

Elevated serum irisin levels in boys with central precocious puberty independent of BMI

D Zeng, Y Chen, T Xie, W Qin, Q Meng… - Endokrynologia …, 2024 - journals.viamedica.pl
Introduction: Central precocious puberty (CPP) is a prevalent endocrine disorder. Research
has indicated that pubertal development is linked to nutritional metabolism. Irisin, a novel …