The signaling component of the mammalian Fibroblast Growth Factor (FGF) family is
comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF …

Fibroblast growth factor (FGF) signaling pathways are essential regulators of vertebrate
skeletal development. FGF signaling regulates development of the limb bud and formation of …

DNA methylation plays a critical role in establishing and maintaining cellular identity.
However, it is frequently dysregulated during tumor development and is closely intertwined …

Combination therapies consisting of immune checkpoint inhibitors plus anti-VEGF therapy
show enhanced antitumor activity and are approved treatments for patients with renal cell …

The 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their
cellular responses by binding to and activating the different isoforms encoded by the four …

Autosomal dominant mutations in fibroblast growth factor receptor 3 (FGFR3) cause
achondroplasia (Ach), the most common form of dwarfism in humans, and related …

The fibroblast growth factor receptor (FGFR) cascade plays crucial roles in tumor cell
proliferation, angiogenesis, migration and survival. Accumulating evidence suggests that in …

In mammals, fibroblast growth factors (FGFs) are encoded by 22 genes. FGFs bind and
activate alternatively spliced forms of four tyrosine kinase FGF receptors (FGFRs 1–4). The …

Runx2 and Sp7 are essential transcription factors for osteoblast differentiation. However, the
molecular mechanisms responsible for the proliferation of osteoblast progenitors remain …

Over the last decade the identification of mutations in the receptors for fibroblast growth
factors (FGFs) has defined essential roles for FGF signaling in both endochondral and …