Steroidogenesis, the processes by which cholesterol is converted to steroid hormones,
involves transport proteins, enzymes, redox partners and cofactors. Most steroidogenic …

Recent years have seen significant advances in our understanding of the development and
function of the adrenal gland together with further insights into the physiologic and …

Liquid chromatography tandem mass spectrometry (LC/MS/MS) is replacing classical
methods for steroid hormone analysis. It requires small sample volumes and has given rise …

Cytochrome P450 oxidoreductase (POR) is an enzyme that is essential for multiple
metabolic processes, chiefly among them are reactions catalyzed by cytochrome P450 …

A newborn infant with ambiguous genitalia is a complex enough problem to unravel without
any further clouding by confusing terms. The nomenclature 'intersex','hermaphrodite'and …

Masculinization depends on adequate production of testosterone by the fetal testis within a
specific “masculinization programming window.” Disorders resulting from subtle deficiencies …

Steroid biosynthesis and metabolism are reflected by the serum steroid metabolome and, in
even more detail, by the 24-hour urine steroid metabolome, which can provide unique …

Dihydrotestosterone (DHT) is the androgen responsible for formation of the male external
genitalia during embryogenesis and for most androgen-mediated events at male puberty. In …

Human sexual determination is initiated by a cascade of genes that lead to the development
of the fetal gonad. Whereas development of the female external genitalia does not require …

The biosynthesis of steroid hormones requires the coordinated expression of the enzymes
that comprise the pathways via which specific hormones are synthesized. These pathways …