Combinatorial strategies in fluorescent probe development

M Vendrell, D Zhai, JC Er, YT Chang - Chemical reviews, 2012 - ACS Publications
The need for understanding essential recognition events in chemistry and biology has
directed considerable efforts toward the development of chemical probes. Fluorescent …

Learn from antibody–drug conjugates: consideration in the future construction of peptide-drug conjugates for cancer therapy

M Wu, W Huang, N Yang, Y Liu - Experimental Hematology & Oncology, 2022 - Springer
Cancer is one of the leading causes of death worldwide due to high heterogeneity. Although
chemotherapy remains the mainstay of cancer therapy, non-selective toxicity and drug …

Recent innovations in peptide based targeted drug delivery to cancer cells

Y Gilad, M Firer, G Gellerman - Biomedicines, 2016 - mdpi.com
Targeted delivery of chemotherapeutics and diagnostic agents conjugated to carrier ligands
has made significant progress in recent years, both in regards to the structural design of the …

Yeast display evolution of a kinetically efficient 13-amino acid substrate for lipoic acid ligase

S Puthenveetil, DS Liu, KA White… - Journal of the …, 2009 - ACS Publications
Escherichia coli lipoic acid ligase (LplA) catalyzes ATP-dependent covalent ligation of lipoic
acid onto specific lysine side chains of three acceptor proteins involved in oxidative …

Targeted capture of Chinese hamster ovary host cell proteins: Peptide ligand discovery

RA Lavoie, A di Fazio, RK Blackburn… - International journal of …, 2019 - mdpi.com
The growing integration of quality-by-design (QbD) concepts in biomanufacturing calls for a
detailed and quantitative knowledge of the profile of impurities and their impact on the …

Peptides and pseudopeptide ligands: a powerful toolbox for the affinity purification of current and next-generation biotherapeutics

W Chu, R Prodromou, KN Day, JD Schneible… - … of Chromatography A, 2021 - Elsevier
Following the consolidation of therapeutic proteins in the fight against cancer, autoimmune,
and neurodegenerative diseases, recent advancements in biochemistry and biotechnology …

Bead-based screening in chemical biology and drug discovery

VV Komnatnyy, TE Nielsen, K Qvortrup - Chemical Communications, 2018 - pubs.rsc.org
High-throughput screening is an important component of the drug discovery process. The
screening of libraries containing hundreds of thousands of compounds requires assays …

High-throughput screening of one-bead–one-compound peptide libraries using intact cells

CF Cho, B Behnam Azad, LG Luyt… - ACS combinatorial …, 2013 - ACS Publications
Screening approaches based on one-bead–one-compound (OBOC) combinatorial libraries
have facilitated the discovery of novel peptide ligands for cellular targeting in cancer and …

Latest advances in OBOC peptide libraries. Improvements in screening strategies and enlarging the family from linear to cyclic libraries

M C. Martínez-Ceron, S L. Giudicessi… - Current …, 2016 - benthamdirect.com
Solid phase screenings of one bead one compound (OBOC) libraries have been widely
used to find ligands with pharmacological and analytical uses, and to purify or detect …

Peptide affinity chromatography applied to therapeutic antibodies purification

GR Barredo-Vacchelli, SL Giudicessi… - International Journal of …, 2021 - Springer
The interest in therapeutic monoclonal antibodies (mAbs) has significantly grown in the
pharmaceutical industry, exceeding 100 FDA mAbs approved. Although the upstream …