Combination therapy, a treatment modality that combines two or more therapeutic agents, is
a cornerstone of cancer therapy. The amalgamation of anti-cancer drugs enhances efficacy …

Carbonic anhydrases (CAs, EC 4.2. 1.1) catalyse the interconversion between CO2 and
bicarbonate as well as other hydrolytic reactions. Among the six genetic families known to …

Sulfonamides are among the most promising potential inhibitors for carbonic anhydrases
(CAs), which are pharmaceutically relevant targets for treating several disease conditions …

The link between cancer metabolism and immunosuppression, inflammation and immune
escape has generated major interest in investigating the effects of low pH on tumor …

Six genetic families of the enzyme carbonic anhydrase (CA, EC 4.2. 1.1) were described to
date. Inhibition of CAs has pharmacologic applications in the field of antiglaucoma …

The pH in tumour cells and the tumour microenvironment has played important roles in
cancer development and treatment. It was thought that both the extracellular and …

The high metabolic rate of tumours often leads to acidosis and hypoxia in poorly perfused
regions. Tumour cells have thus evolved the ability to function in a more acidic environment …

Coumarin and benzimidazole are privileged structures in medicinal chemistry and are
widely used in drug discovery and development due to their vast biological properties. The …

Olivetol is a pioneer in diverse syntheses of tetrahydrocannabinol. It is produced by a type of
insects, which is used as a pheromone, antiseptic, or repellent agent. In this study, we …

The algal pyrenoid is a large plastid body, where the majority of the CO2-fixing enzyme,
ribulose-1, 5-bisphosphate carboxylase/oxygenase (RubisCO) resides, and it is proposed to …