Reactive oxygen species (ROS) and their products are components of cell signaling
pathways and play important roles in cellular physiology and pathophysiology. Under …

Significance: The primary function of NADPH oxidases (NOX1–5 and dual oxidases
DUOX1/2) is to produce reactive oxygen species (ROS). If inadequately regulated, NOX …

Both protein kinase C (PKC) and reactive oxygen species (ROS) are well-known signaling
messengers cross-talking with each other to activate mitogen-activated protein kinases …

Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths in
men, and the sixth in women. Non-alcoholic fatty liver disease (NAFLD) is now one of the …

NF-E2-related factor 2 (NRF2) is a basic leucine zipper transcription factor, a master
regulator of redox homeostasis regulating a variety of genes for antioxidant and …

NOX/DUOX enzymes are transmembrane proteins that carry electrons through biological
membranes generating reactive oxygen species. The NOX family is composed of seven …

Dysregulated oxidative metabolism is a well-recognized aspect of cancer biology, and many
therapeutic strategies are based on targeting cancers by altering cellular redox pathways …

Simple Summary Protein kinase C (PKC) isozymes play key roles in the proliferation,
differentiation, survival, migration, invasion, apoptosis, and anticancer drug resistance of …

Abstract Dual oxidase 2 (DUOX2) is an important regulatory protein in the organic process of
thyroid hormone iodine. Mounting evidence suggests that DUOX2 plays a crucial role in the …

Organoids derived from epithelial tumors have recently been utilized as a preclinical model
in basic and translational studies. This model is considered to represent the original tumor in …