The human Y chromosome is intriguing not only because it harbours the master-switch gene
that determines gender but also because of its unusual evolutionary history. The Y …

Spermatogenesis is a complex differentiation process coordinated spatiotemporally across
and along seminiferous tubules. Cellular heterogeneity has made it challenging to obtain …

The Drosophila melanogaster fuzzy onions (fzo) gene encodes the first known protein
mediator of mitochondrial fusion. During Drosophila spermatogenesis, mitochondria in early …

Proper differentiation of sperm from germline stem cells, essential for production of the next
generation, requires dramatic changes in gene expression that drive remodeling of almost …

In Drosophila, genes expressed in males tend to accumulate on autosomes and are
underrepresented on the X chromosome. In particular, genes expressed in testis have been …

Sexual reproduction is such a successful way of creating progeny with subtle genetic
variations that the vast majority of eukaryotic species use it. In mammals, it involves the …

Acrosin (ACR), a serine proteinase located in the acrosome of the sperm, has been
presumed to be involved in the recognition and binding of the sperm to the zona pellucida of …

The aly, can, mia and sa genes of Drosophila are essential in males both for the G2-meiosis
I transition and for onset of spermatid differentiation. Function of all four genes is required for …

Transcriptional activity is repressed due to the packaging of sperm chromatins during
spermiogenesis. The detection of numerous transcripts in sperm, however, raises the …

The evolution of heteromorphic sex chromosomes (eg, XY in males or ZW in females) has
repeatedly elicited the evolution of two kinds of chromosome-specific regulation: dosage …