Genomics has contributed to the treatment of a fraction of cancer patients. However, there is
a need to profile the proteins that define the phenotype of cancer and its pathogenesis. The …

Significance: The mitochondrial oxidative phosphorylation (OXPHOS) system, comprising
the electron transport chain and ATP synthase, generates membrane potential, drives ATP …

Mitochondrial metabolism has emerged as a promising target against the mechanisms of
tumor growth. Herein, we have screened an FDA-approved library to identify drugs that …

Objectives Osteosarcoma is highly aggressive and prone to metastasis, with a poor
prognosis. Increasing evidence identified anoikis has a critical effect in tumor metastasis and …

The mitochondrial ATP synthase emerges as key hub of cellular functions controlling the
production of ATP, cellular signaling, and fate. It is regulated by the ATPase inhibitory factor …

Colorectal cancer (CRC) is second most commonly diagnosed cancer with high morbidity
and mortality. The heterogeneity of CRC makes clinical treatment tremendously challenging …

Significance: The architecture of the mitochondrial network and cristae critically impact cell
differentiation and identity. Cells undergoing metabolic reprogramming to aerobic glycolysis …

The endogenous inhibitor of ATP synthase is a protein of about 10 kDa, known as IF1 which
binds to the catalytic domain of the enzyme during ATP hydrolysis. The main role of IF1 …

Simple Summary Cancer is a global health problem with high personal and economic
burden worldwide. The reprogramming of metabolism experienced by carcinomas offers a …

Within the tumor microenvironment, the fight between the immune system and cancer
influences tumor transformation. Metastasis formation is an important stage in the …