NPM1-mutated acute myeloid leukemia: from bench to bedside
The nucleophosmin (NPM1) gene encodes for a multifunctional protein with prominent
nucleolar localization that shuttles between nucleus and cytoplasm. NPM1 mutations …
nucleolar localization that shuttles between nucleus and cytoplasm. NPM1 mutations …
Current status and future perspectives in targeted therapy of NPM1-mutated AML
Abstract Nucleophosmin 1 (NPM1) is a nucleus-cytoplasmic shuttling protein which is
predominantly located in the nucleolus and exerts multiple functions, including regulation of …
predominantly located in the nucleolus and exerts multiple functions, including regulation of …
Integrated single-cell analysis maps the continuous regulatory landscape of human hematopoietic differentiation
Human hematopoiesis involves cellular differentiation of multipotent cells into progressively
more lineage-restricted states. While the chromatin accessibility landscape of this process …
more lineage-restricted states. While the chromatin accessibility landscape of this process …
[HTML][HTML] Mutant NPM1 maintains the leukemic state through HOX expression
L Brunetti, MC Gundry, D Sorcini, AG Guzman… - Cancer cell, 2018 - cell.com
NPM1 is the most frequently mutated gene in cytogenetically normal acute myeloid leukemia
(AML). In AML cells, NPM1 mutations result in abnormal cytoplasmic localization of the …
(AML). In AML cells, NPM1 mutations result in abnormal cytoplasmic localization of the …
Identification of regulatory networks in HSCs and their immediate progeny via integrated proteome, transcriptome, and DNA methylome analysis
N Cabezas-Wallscheid, D Klimmeck, J Hansson… - Cell stem cell, 2014 - cell.com
In this study, we present integrated quantitative proteome, transcriptome, and methylome
analyses of hematopoietic stem cells (HSCs) and four multipotent progenitor (MPP) …
analyses of hematopoietic stem cells (HSCs) and four multipotent progenitor (MPP) …
Physiological and pathological roles for microRNAs in the immune system
Mammalian microRNAs (miRNAs) have recently been identified as important regulators of
gene expression, and they function by repressing specific target genes at the post …
gene expression, and they function by repressing specific target genes at the post …
Covalent histone modifications—miswritten, misinterpreted and mis-erased in human cancers
Post-translational modification of histones provides an important regulatory platform for
processes such as gene transcription and DNA damage repair. It has become increasingly …
processes such as gene transcription and DNA damage repair. It has become increasingly …
CDK9: a comprehensive review of its biology, and its role as a potential target for anti-cancer agents
AT Anshabo, R Milne, S Wang, H Albrecht - Frontiers in oncology, 2021 - frontiersin.org
Cyclin-dependent kinases (CDKs) are proteins pivotal to a wide range of cellular functions,
most importantly cell division and transcription, and their dysregulations have been …
most importantly cell division and transcription, and their dysregulations have been …
BloodSpot: a database of gene expression profiles and transcriptional programs for healthy and malignant haematopoiesis
FO Bagger, D Sasivarevic, SH Sohi… - Nucleic acids …, 2016 - academic.oup.com
Research on human and murine haematopoiesis has resulted in a vast number of gene-
expression data sets that can potentially answer questions regarding normal and aberrant …
expression data sets that can potentially answer questions regarding normal and aberrant …
Human haematopoietic stem cell development: from the embryo to the dish
Haematopoietic stem cells (HSCs) emerge during embryogenesis and give rise to the adult
haematopoietic system. Understanding how early haematopoietic development occurs is of …
haematopoietic system. Understanding how early haematopoietic development occurs is of …