Many protein and mRNA species occur at low molecular counts within cells, and hence are
subject to large stochastic fluctuations in copy numbers over time. Development of …

Hormone therapy in the form of androgen deprivation is a major treatment for advanced
prostate cancer. However, if such therapy is overly prolonged, tumour cells may become …

Considerable evidence suggests that during the progression of complex diseases, the
deteriorations are not necessarily smooth but are abrupt and may cause a critical transition …

The main purpose of this study is to compare two different feedback controllers for the
stabilization of quiet standing in humans, taking into account that the intrinsic ankle stiffness …

In this introductory article, we survey the contents of this Theme Issue. This Theme Issue
deals with a fertile region of hybrid dynamical systems that are characterized by the …

We propose a mathematical model that quantitatively reproduces the dynamics of the serum
prostate-specific antigen (PSA) level under intermittent androgen suppression (IAS) for …

A growing number of studies shows that it is possible to induce a phenotypic transformation
of cancer cells from malignant to benign. This process is currently known as “tumor …

The agenda of pharmacology discovery in the field of personalized oncology was dictated
by the search of molecular targets assumed to deterministically drive tumor development. In …

The early diagnosis and investigation of the pathogenic mechanisms of complex diseases
are the most challenging problems in the fields of biology and medicine. Network-based …

Non-smooth or even abrupt state changes exist during many biological processes, eg, cell
differentiation processes, proliferation processes, or even disease deterioration processes …