Cerebral ischemic stroke is characterized by acute ischemia in a certain part of the brain,
which leads to brain cells necrosis, apoptosis, ferroptosis, pyroptosis, etc. At present, there …

Abstract Nuclear Factor Erythroid 2-related factor 2 (Nrf2) is a transcription factor that
regulates the expression of genes involved in the metabolism, immune response, cellular …

Neurodegenerative disorders affect more than fifty million Americans each year and
represent serious health threats as the population ages. Neuroinflammation and oxidative …

With the recognition of the endogenous signaling roles and pharmacological functions of
carbon monoxide (CO), there is an increasing need to understand CO's mechanism of …

Carbon monoxide (CO) is generated by heme oxygenase-1 (HO-1) and displays important
signaling, anti-apoptotic and anti-inflammatory activities, indicating that pharmacological …

Epidemiological evidence showed that patients suffering from obesity and T2DM are
significantly at higher risk for chronic low-grade inflammation, oxidative stress, nonalcoholic …

Intrauterine growth restriction (IUGR) affects up to 10% of pregnancies in Western societies.
IUGR is a strong predictor of reduced short-term neonatal survival and impairs long-term …

Spinal cord injury (SCI) is a serious, disabling injury to the central nervous system that can
lead to motor, sensory, and autonomic dysfunction below the injury plane. SCI can be …

Carbon monoxide (CO) is a known endogenous signaling molecule with potential
therapeutic indications in treating inflammation, cancer, neuroprotection, and sickle cell …

Background and Purpose Haem oxygenase‐1 (HO‐1) is induced by thiazolidinediones
including rosiglitazone and exerts anti‐inflammatory effects in various models. However, the …