Epigenetic research has rapidly evolved into a dynamic field of genome biology. Chromatin
regulation has been proved to be an essential aspect for all genomic processes, including …

DNA double strand breaks (DSBs) are the most threatening type of DNA lesions and must
be repaired properly in order to inhibit severe diseases and cell death. There are four major …

Double-strand breaks (DSBs) are one of the most toxic forms of DNA damage and represent
a major source of genomic instability. Members of the bromodomain and extra-terminal …

The adenosine 5′-triphosphate (ATP)–dependent chromatin remodeler SMARCAD1 acts
on nucleosomes during DNA replication, repair, and transcription, but despite its implication …

Facilitates chromatin transcription (FACT) is a histone chaperone, which accomplishes both
nucleosome assembly and disassembly. Our combined cryo-electron microscopy (EM) and …

Centromeres are defined by a self-propagating chromatin structure based on stable
inheritance of CENP-A containing nucleosomes. Here, we present a genetic screen coupled …

Proliferating cell nuclear antigen (PCNA) is a homo-trimeric clamp complex that serves as
the molecular hub for various DNA transactions, including DNA synthesis and post …

Chromatin remodelers act in an ATP-dependent manner to modulate chromatin structure
and thus genome function. Here, we report that the Arabidopsis (Arabidopsis thaliana) …

Pancreatic cancer (PC) is one of the most lethal diseases, characterized by early metastasis
and high mortality. Subunits of the SWI/SNF complex have been identified in many studies …

Chromosome segregation during cell division is driven by mitotic spindle attachment to the
centromere region on each chromosome. Centromeres form a protein scaffold defined by …