Dendritic structural plasticity and neuropsychiatric disease
MP Forrest, E Parnell, P Penzes - Nature Reviews Neuroscience, 2018 - nature.com
The structure of neuronal circuits that subserve cognitive functions in the brain is shaped
and refined throughout development and into adulthood. Evidence from human and animal …
and refined throughout development and into adulthood. Evidence from human and animal …
Network analysis for a network disorder: the emerging role of graph theory in the study of epilepsy
Recent years have witnessed a paradigm shift in the study and conceptualization of
epilepsy, which is increasingly understood as a network-level disorder. An emblematic case …
epilepsy, which is increasingly understood as a network-level disorder. An emblematic case …
Identification of epilepsy-associated neuronal subtypes and gene expression underlying epileptogenesis
Epilepsy is one of the most common neurological disorders, yet its pathophysiology is poorly
understood due to the high complexity of affected neuronal circuits. To identify dysfunctional …
understood due to the high complexity of affected neuronal circuits. To identify dysfunctional …
Quantitative analysis of high-frequency oscillations (80–500 Hz) recorded in human epileptic hippocampus and entorhinal cortex
High-frequency oscillations (100–200 Hz), termed ripples, have been identified in
hippocampal (Hip) and entorhinal cortical (EC) areas of rodents and humans. In contrast …
hippocampal (Hip) and entorhinal cortical (EC) areas of rodents and humans. In contrast …
Imaging structural and functional brain networks in temporal lobe epilepsy
BC Bernhardt, SJ Hong, A Bernasconi… - Frontiers in human …, 2013 - frontiersin.org
Early imaging studies in temporal lobe epilepsy (TLE) focused on the search for mesial
temporal sclerosis, as its surgical removal results in clinically meaningful improvement in …
temporal sclerosis, as its surgical removal results in clinically meaningful improvement in …
Ammon's horn sclerosis: a maldevelopmental disorder associated with temporal lobe epilepsy
IB MD, MT MRCPath, OD Wiestler - Brain pathology, 2002 - Wiley Online Library
Ammon's horn sclerosis (AHS) is the major neuropathological substrate in patients with
temporal lobe epilepsy (TLE). Histopathological hallmarks include segmental loss of …
temporal lobe epilepsy (TLE). Histopathological hallmarks include segmental loss of …
High‐frequency oscillations recorded in human medial temporal lobe during sleep
The presence of fast ripple oscillations (FRs, 200–500Hz) has been confirmed in rodent
epilepsy models but has not been observed in nonepileptic rodents, suggesting that FRs are …
epilepsy models but has not been observed in nonepileptic rodents, suggesting that FRs are …
Effects of type 1 diabetes on gray matter density as measured by voxel-based morphometry
The effects of type 1 diabetes and key metabolic variables on brain structure are not well
understood. Sensitive methods of assessing brain structure, such as voxel-based …
understood. Sensitive methods of assessing brain structure, such as voxel-based …
Cortical thickness analysis in temporal lobe epilepsy: reproducibility and relation to outcome
Objective: To assess the reproducibility of neocortical atrophy and its clinical significance
across the spectrum of temporal lobe epilepsy (TLE), in particular with respect to …
across the spectrum of temporal lobe epilepsy (TLE), in particular with respect to …
The biology of epilepsy genes
JL Noebels - Annual review of neuroscience, 2003 - annualreviews.org
▪ Abstract Mutations in over 70 genes now define biological pathways leading to epilepsy,
an episodic dysrhythmia of the cerebral cortex marked by abnormal network …
an episodic dysrhythmia of the cerebral cortex marked by abnormal network …