Peroxisome proliferator-activated receptor-α (PPARα), PPARδ and PPARγ are transcription
factors that regulate gene expression following ligand activation. PPARα increases cellular …

Traditionally, peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α), a 91 kDa
transcription factor, regulates lipid metabolism and long-chain fatty acid oxidation by …

Dramatic maturational changes occur in cardiac energy metabolism during cardiac
development, differentiation, and postnatal growth. These changes in energy metabolism …

Activation of nuclear factor (NF)-κB, one of the most investigated transcription factors, has
been found to control multiple cellular processes in cancer including inflammation …

Metabolic disorders such as obesity, insulin resistance and type 2 diabetes mellitus are all
linked to cardiovascular diseases such as cardiac hypertrophy and heart failure. Diabetic …

Obesity is a growing threat to global health by virtue of its association with insulin resistance,
glucose intolerance, hypertension, and dyslipidemia, collectively known as the metabolic …

Aims A complex set of metabolic and inflammatory processes are involved in the
development of cardiac hypertrophy. Accumulating evidence indicates an important role for …

The peroxisome proliferator-activated receptors, PPARα, PPARβ, and PPARγ, are a family of
transcription factors activated by a diversity of molecules including fatty acids and fatty acid …

Capsaicin, the phytochemical responsible for the spiciness of peppers, has the potential to
modulate metabolism via activation of transient receptor potential vanilloid 1 (TRPV1) …

cAMP responsive element-binding protein (CREB) is one of the most intensively studied
phosphorylation-dependent transcription factors that provide evolutionarily conserved …