Cell transplantation therapy for spinal cord injury

P Assinck, GJ Duncan, BJ Hilton, JR Plemel… - Nature …, 2017 - nature.com
Spinal cord injury can lead to severe motor, sensory and autonomic dysfunction. Currently,
there is no effective treatment for the injured spinal cord. The transplantation of Schwann …

From basics to clinical: a comprehensive review on spinal cord injury

NA Silva, N Sousa, RL Reis, AJ Salgado - Progress in neurobiology, 2014 - Elsevier
Spinal cord injury (SCI) is a devastating neurological disorder that affects thousands of
individuals each year. Over the past decades an enormous progress has been made in our …

Spinal cord injury: pathophysiology, treatment strategies, associated challenges, and future implications

K Venkatesh, SK Ghosh, M Mullick… - Cell and tissue …, 2019 - Springer
Axonal regeneration and formation of tripartite (axo-glial) junctions at damaged sites is a
prerequisite for early repair of injured spinal cord. Transplantation of stem cells at such sites …

Therapeutic repair for spinal cord injury: combinatory approaches to address a multifaceted problem

JM Griffin, F Bradke - EMBO molecular medicine, 2020 - embopress.org
The recent years saw the advent of promising preclinical strategies that combat the
devastating effects of a spinal cord injury (SCI) that are progressing towards clinical trials …

The leading edge: Emerging neuroprotective and neuroregenerative cell-based therapies for spinal cord injury

CS Ahuja, A Mothe, M Khazaei… - Stem cells …, 2020 - academic.oup.com
Spinal cord injuries (SCIs) are associated with tremendous physical, social, and financial
costs for millions of individuals and families worldwide. Rapid delivery of specialized …

Neural tissue engineering: strategies for repair and regeneration

CE Schmidt, JB Leach - Annual review of biomedical …, 2003 - annualreviews.org
▪ Abstract Nerve regeneration is a complex biological phenomenon. In the peripheral
nervous system, nerves can regenerate on their own if injuries are small. Larger injuries …

Safety of autologous human schwann cell transplantation in subacute thoracic spinal cord injury

KD Anderson, JD Guest, WD Dietrich… - Journal of …, 2017 - liebertpub.com
The rationale for implantation of autologous human Schwann cells (SCs) in persons with
subacute spinal cord injury (SCI) is based on evidence that transplanted SCs are …

Therapeutic interventions after spinal cord injury

S Thuret, LDF Moon, FH Gage - Nature Reviews Neuroscience, 2006 - nature.com
Spinal cord injury (SCI) can lead to paraplegia or quadriplegia. Although there are no fully
restorative treatments for SCI, various rehabilitative, cellular and molecular therapies have …

A systematic review of cellular transplantation therapies for spinal cord injury

W Tetzlaff, EB Okon, S Karimi-Abdolrezaee… - Journal of …, 2011 - liebertpub.com
Cell transplantation therapies have become a major focus in pre-clinical research as a
promising strategy for the treatment of spinal cord injury (SCI). In this article, we …

Myelin damage and repair in pathologic CNS: challenges and prospects

A Alizadeh, SM Dyck… - Frontiers in molecular …, 2015 - frontiersin.org
Injury to the central nervous system (CNS) results in oligodendrocyte cell death and
progressive demyelination. Demyelinated axons undergo considerable physiological …