Fat of the gut: epithelial phospholipids in inflammatory bowel diseases

LV Boldyreva, MV Morozova, SS Saydakova… - International journal of …, 2021 - mdpi.com
Inflammatory bowel diseases (IBD) comprise a distinct set of clinical symptoms resulting
from chronic inflammation within the gastrointestinal (GI) tract. Despite the significant …

Atypical antiinflammatory activation of microglia induced by apoptotic neurons: possible role of phosphatidylserine-phosphatidylserine receptor interaction

R De Simone, MA Ajmone-Cat, L Minghetti - Molecular neurobiology, 2004 - Springer
In the central nervous system (CNS), apoptosis plays an important role during development
and is a primary pathogenic mechanism in several adult neurodegenerative diseases. A …

A major fraction of glycosphingolipids in model and cellular cholesterol-containing membranes is undetectable by their binding proteins

R Mahfoud, A Manis, B Binnington, C Ackerley… - Journal of Biological …, 2010 - ASBMB
Glycosphingolipids (GSLs) accumulate in cholesterol-enriched cell membrane domains and
provide receptors for protein ligands. Lipid-based" aglycone" interactions can influence GSL …

Atp8a1 deficiency is associated with phosphatidylserine externalization in hippocampus and delayed hippocampus‐dependent learning

K Levano, V Punia, M Raghunath… - Journal of …, 2012 - Wiley Online Library
J. Neurochem.(2012) 120, 302–313. Abstract The molecule responsible for the enzyme
activity plasma membrane (PM) aminophospholipid translocase (APLT), which catalyzes …

Persistence of effector memory Th1 cells is regulated by Hopx

I Albrecht, U Niesner, M Janke… - European journal of …, 2010 - Wiley Online Library
Th1 cells are prominent in inflamed tissue, survive conventional immunosuppression, and
are believed to play a pivotal role in driving chronic inflammation. Here, we identify …

Acid sphingomyelinase and inhibition by phosphate ion: role of inhibition by phosphatidyl‐myo‐inositol 3,4,5‐triphosphate in oligodendrocyte cell signaling

FD Testai, MA Landek, R Goswami… - Journal of …, 2004 - Wiley Online Library
There is ample evidence that both acid (ASMase) and neutral (NSMase) sphingomyelinases
play a role in cell death so inhibitors of either enzyme could have significant value as …

[HTML][HTML] Oxidative stress causes membrane phospholipid rearrangement and shedding from RBC membranes—an NMR study

I Freikman, J Amer, JS Cohen, I Ringel… - Biochimica et Biophysica …, 2008 - Elsevier
Nuclear Magnetic Resonance (NMR) spectroscopy was used to investigate the relationship
between oxidative stress experienced by RBCs and their phospholipid content and …

[HTML][HTML] Exogenous phosphatidylethanolamine induces apoptosis of human hepatoma HepG2 cells via the bcl-2/Bax pathway

Y Yao, C Huang, ZF Li, AY Wang, LY Liu… - World journal of …, 2009 - ncbi.nlm.nih.gov
AIM: To investigate the signaling pathways implicated in phosphatidylethanolamine (PE)-
induced apoptosis of human hepatoma HepG2 cells. METHODS: Inhibitory effects of PE on …

Differential regulation of ceramide in lipid‐rich microdomains (rafts): Antagonistic role of palmitoyl: protein thioesterase and neutral sphingomyelinase 2

R Goswami, M Ahmed, J Kilkus, T Han… - Journal of …, 2005 - Wiley Online Library
Cell differentiation and myelination involve a fine balance between stasis and programmed
cell death, yet the genes that regulate this have not been clearly defined. We therefore …

Involvement of sodium in early phosphatidylserine exposure and phospholipid scrambling induced by P2X7 purinoceptor activation in thymocytes

MP Courageot, S Lépine, M Hours, F Giraud… - Journal of Biological …, 2004 - ASBMB
Extracellular ATP (ATP ec), a possible effector in thymocyte selection, induces thymocyte
death via purinoceptor activation. We show that ATP ec induced cell death by apoptosis …