Genetic drift, selection and the evolution of the mutation rate
As one of the few cellular traits that can be quantified across the tree of life, DNA-replication
fidelity provides an excellent platform for understanding fundamental evolutionary …
fidelity provides an excellent platform for understanding fundamental evolutionary …
Determinants of the rate of protein sequence evolution
The rate and mechanism of protein sequence evolution have been central questions in
evolutionary biology since the 1960s. Although the rate of protein sequence evolution …
evolutionary biology since the 1960s. Although the rate of protein sequence evolution …
Synonymous mutations in representative yeast genes are mostly strongly non-neutral
Synonymous mutations in protein-coding genes do not alter protein sequences and are thus
generally presumed to be neutral or nearly neutral,,,–. Here, to experimentally verify this …
generally presumed to be neutral or nearly neutral,,,–. Here, to experimentally verify this …
Biophysics of protein evolution and evolutionary protein biophysics
The study of molecular evolution at the level of protein-coding genes often entails comparing
large datasets of sequences to infer their evolutionary relationships. Despite the importance …
large datasets of sequences to infer their evolutionary relationships. Despite the importance …
Strong Purifying Selection at Synonymous Sites in D. melanogaster
Synonymous sites are generally assumed to be subject to weak selective constraint. For this
reason, they are often neglected as a possible source of important functional variation. We …
reason, they are often neglected as a possible source of important functional variation. We …
Is the mutation rate lower in genomic regions of stronger selective constraints?
A study of the plant Arabidopsis thaliana detected lower mutation rates in genomic regions
where mutations are more likely to be deleterious, challenging the principle that …
where mutations are more likely to be deleterious, challenging the principle that …
Role of mRNA structure in the control of protein folding
G Faure, AY Ogurtsov, SA Shabalina… - Nucleic acids …, 2016 - academic.oup.com
Specific structures in mRNA modulate translation rate and thus can affect protein folding.
Using the protein structures from two eukaryotes and three prokaryotes, we explore the …
Using the protein structures from two eukaryotes and three prokaryotes, we explore the …
Evidence for Widespread Positive and Negative Selection in Coding and Conserved Noncoding Regions of Capsella grandiflora
The extent that both positive and negative selection vary across different portions of plant
genomes remains poorly understood. Here, we sequence whole genomes of 13 Capsella …
genomes remains poorly understood. Here, we sequence whole genomes of 13 Capsella …
Genome-wide maps of ribosomal occupancy provide insights into adaptive evolution and regulatory roles of uORFs during Drosophila development
Upstream open reading frames (uORFs) play important roles in regulating the main coding
DNA sequences (CDSs) via translational repression. Despite their prevalence in the …
DNA sequences (CDSs) via translational repression. Despite their prevalence in the …
Expression level is a major modifier of the fitness landscape of a protein coding gene
Z Wu, X Cai, X Zhang, Y Liu, G Tian, JR Yang… - Nature Ecology & …, 2022 - nature.com
The phenotypic consequence of a genetic mutation depends on many factors including the
expression level of a gene. However, a comprehensive quantification of this expression …
expression level of a gene. However, a comprehensive quantification of this expression …