Quercetin is a phenolic flavonol compound with established antioxidant, anti-inflammatory,
and immuno-stimulant properties. Recent studies demonstrate the potential of quercetin …

Selenium is an indispensable trace element for all living organisms. It is an essential
structural component of several selenium-dependent enzymes, which support the human …

After 100 years of chemotherapy with impractical and toxic drugs, an oral cure for human
African trypanosomiasis (HAT) is available: Fexinidazole. In this case, we review the history …

The monkeypox disease (MPX) outbreak of 2022 has been reported in more than one
hundred countries and is becoming a global concern. Unfortunately, only a few treatments …

Clostridioides difficile infection (CDI) is an urgent threat and unmet medical need. The
current treatments for CDI are not enough to fight the burden of CDI and recurrent CDI (r …

Chagas disease and leishmaniasis are neglected diseases of high priority as a public health
problem. Pharmacotherapy is based on the administration of a few drugs, which exhibit …

Due to the lack of specific vaccines, management of the trypanosomatid-caused neglected
tropical diseases (sleeping sickness, Chagas disease and leishmaniasis) relies exclusively …

The multidrug-resistant (MDR) human immunodeficiency virus 1 (HIV-1) infection is an
unmet medical need. HIV-1 capsid plays an important role at different stages of the HIV-1 …

Each year, new drugs are introduced to the market, representing structures that have affinity
for biological targets implicated in human diseases and conditions. These new chemical …

Human African trypanosomiasis (sleeping sickness) and American trypanosomiasis
(Chagas disease) are vector-borne neglected tropical diseases, caused by the protozoan …