Addressing the perfect storm: biomarkers in obesity and pathophysiology of cardiometabolic risk

K Aleksandrova, D Mozaffarian, T Pischon - Clinical chemistry, 2018 - academic.oup.com
BACKGROUND The worldwide rise of obesity has provoked intensified research to better
understand its pathophysiology as a means for disease prevention. Several biomarkers that …

Milk's role as an epigenetic regulator in health and disease

BC Melnik, G Schmitz - Diseases, 2017 - mdpi.com
It is the intention of this review to characterize milk's role as an epigenetic regulator in health
and disease. Based on translational research, we identify milk as a major epigenetic …

Structural insights into FTO's catalytic mechanism for the demethylation of multiple RNA substrates

X Zhang, LH Wei, Y Wang, Y Xiao… - Proceedings of the …, 2019 - National Acad Sciences
FTO demethylates internal N 6-methyladenosine (m6A) and N 6, 2′-O-dimethyladenosine
(m6Am; at the cap+ 1 position) in mRNA, m6A and m6Am in snRNA, and N 1 …

Intermittent fasting modulates the intestinal microbiota and improves obesity and host energy metabolism

X Hu, K Xia, M Dai, X Han, P Yuan, J Liu… - npj Biofilms and …, 2023 - nature.com
Intermittent fasting (IF) is a promising paradigm for weight loss which has been shown to
modulate the gut microbiota based on 16S rRNA gene amplicon sequencing. Here, 72 …

Metabolomics based markers predict type 2 diabetes in a 14-year follow-up study

J Liu, S Semiz, SJ van der Lee, A van der Spek… - Metabolomics, 2017 - Springer
Background The growing field of metabolomics has opened up new opportunities for
prediction of type 2 diabetes (T2D) going beyond the classical biochemistry assays …

BMI and lipidomic biomarkers with risk of gestational diabetes in pregnant women

Y Wang, P Wu, Y Huang, Y Ye, X Yang, F Sun, YX Ye… - …, 2022 - Wiley Online Library
Objective The study aimed to identify BMI‐related lipids and to explore the role of lipids
linking BMI and gestational diabetes mellitus (GDM). Methods Plasma lipidome, height, and …

Membrane phospholipid alteration causes chronic ER stress through early degradation of homeostatic ER-resident proteins

P Shyu Jr, BSH Ng, N Ho, R Chaw, YL Seah… - Scientific reports, 2019 - nature.com
Phospholipid homeostasis in biological membranes is essential to maintain functions of
organelles such as the endoplasmic reticulum. Phospholipid perturbation has been …

Serum metabolite profile associated with incident type 2 diabetes in Koreans: findings from the Korean Genome and Epidemiology Study

SJ Yang, SY Kwak, G Jo, TJ Song, MJ Shin - Scientific reports, 2018 - nature.com
The identification of metabolic alterations in type 2 diabetes (T2D) is useful for elucidating
the pathophysiology of the disease and in classifying high-risk individuals. In this study, we …

Metabolomics prospect of obesity and metabolic syndrome; a systematic review

M Payab, A Tayanloo-Beik, K Falahzadeh… - Journal of Diabetes & …, 2022 - Springer
Purpose Due to growing concerns about the obesity pandemic as a worldwide
phenomenon, a global effort has been made for managing it and associated disorders …

Association of FTO common variant (rs9939609) with body fat in Turkish individuals

D Ağagündüz, M Gezmen-Karadağ - Lipids in health and disease, 2019 - Springer
Background Variations in the fat mass and obesity-associated (FTO) gene (16q12. 2) are
associated with obesity in some populations. This study aimed to determine the relationship …