Tumor mutational burden and heterogeneity has been suggested to fuel resistance to many
targeted therapies. The cytosine deaminase APOBEC proteins have been implicated in the …

Post-transcriptional mechanisms are fundamental safeguards of progenitor cell identity and
are often dysregulated in cancer. Here, we identified regulators of P-bodies as crucial …

Signaling proteins in HSC fate determination are unequally segregated during asymmetric cell
division | Journal of Cell Biology | Rockefeller University Press Skip to Main Content …

Hematopoietic stem cells (HSCs) can self-renew and differentiate for the entire life of an
organism to produce new blood cells when needed. This process is regulated by …

Abstract α‐Cyanostilbene represents one of the easily functionalized aggregation‐induced
emission (AIE) scaffolds. It has been widely adopted for the construction of fluorescent …

Proteasome inhibitors are first-line therapies for multiple myeloma patients and function in
part by disrupting protein homeostasis (proteostasis). Proteasome inhibiton causes an …

Hematopoiesis is a tightly regulated and complex process coordinated by hematopoietic
stem cells (HSCs). When things go wrong during blood development, disease can arise. The …