Myeloid cell–targeted STAT3 inhibition sensitizes head and neck cancers to radiotherapy and T cell–mediated immunity
The tumor microenvironment affects the outcome of radiotherapy against head and neck
squamous cell carcinoma (HNSCC). We recently found that tolerogenic myeloid cells …
squamous cell carcinoma (HNSCC). We recently found that tolerogenic myeloid cells …
STAT3 inhibition combined with CpG immunostimulation activates antitumor immunity to eradicate genetically distinct castration-resistant prostate cancers
Purpose: Prostate cancers show remarkable resistance to emerging immunotherapies,
partly due to tolerogenic STAT3 signaling in tumor-associated myeloid cells. Here, we …
partly due to tolerogenic STAT3 signaling in tumor-associated myeloid cells. Here, we …